Association Between sTREM2, an Immune Biomarker of Microglial Activation, and Aging-Related Brain Volume Changes in Community-Dwelling Older Adults: A 7-Year Follow-Up Study

Association Between sTREM2, an Immune Biomarker of Microglial Activation, and Aging-Related Brain Volume Changes in Community-Dwelling Older Adults: A 7-Year Follow-Up Study

BackgroundThis study aimed to investigate the association between serum levels of soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a soluble form of an innate immune receptor expressed on the microglia, and brain volume in older adults.MethodsThe survey was conducted twice in Kurok...

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Bibliographic Details
Main Authors: Ryuzo Orihashi, Yoshito Mizoguchi, Yoshiomi Imamura, Shigeto Yamada, Akira Monji
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
sTREM2
brain volume
cognitive function
MRI
voxel-based morphometry
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.665612/full

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