p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

mTOR signalling pathway is a critical regulator of cardiac hypertrophy. Here the authors show that two kinases, p38γ and p38δ, control heart growth by promoting mTOR activity via phosphorylation and consequent proteasome degradation of mTOR inhibitor DEPTOR, extending our knowledge of cardiac hypert...

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Main Authors:	Bárbara González-Terán, Juan Antonio López, Elena Rodríguez, Luis Leiva, Sara Martínez-Martínez, Juan Antonio Bernal, Luis Jesús Jiménez-Borreguero, Juan Miguel Redondo, Jesús Vazquez, Guadalupe Sabio
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10477

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spelling	doaj-dc9094845db94cc38fe281710e6607252021-05-11T10:42:38ZengNature Publishing GroupNature Communications2041-17232016-01-017111610.1038/ncomms10477p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradationBárbara González-Terán0Juan Antonio López1Elena Rodríguez2Luis Leiva3Sara Martínez-Martínez4Juan Antonio Bernal5Luis Jesús Jiménez-Borreguero6Juan Miguel Redondo7Jesús Vazquez8Guadalupe Sabio9Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNICmTOR signalling pathway is a critical regulator of cardiac hypertrophy. Here the authors show that two kinases, p38γ and p38δ, control heart growth by promoting mTOR activity via phosphorylation and consequent proteasome degradation of mTOR inhibitor DEPTOR, extending our knowledge of cardiac hypertrophy regulation.https://doi.org/10.1038/ncomms10477
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bárbara González-Terán Juan Antonio López Elena Rodríguez Luis Leiva Sara Martínez-Martínez Juan Antonio Bernal Luis Jesús Jiménez-Borreguero Juan Miguel Redondo Jesús Vazquez Guadalupe Sabio
spellingShingle	Bárbara González-Terán Juan Antonio López Elena Rodríguez Luis Leiva Sara Martínez-Martínez Juan Antonio Bernal Luis Jesús Jiménez-Borreguero Juan Miguel Redondo Jesús Vazquez Guadalupe Sabio p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation Nature Communications
author_facet	Bárbara González-Terán Juan Antonio López Elena Rodríguez Luis Leiva Sara Martínez-Martínez Juan Antonio Bernal Luis Jesús Jiménez-Borreguero Juan Miguel Redondo Jesús Vazquez Guadalupe Sabio
author_sort	Bárbara González-Terán
title	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_short	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_full	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_fullStr	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_full_unstemmed	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_sort	p38γ and δ promote heart hypertrophy by targeting the mtor-inhibitory protein deptor for degradation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-01-01
description	mTOR signalling pathway is a critical regulator of cardiac hypertrophy. Here the authors show that two kinases, p38γ and p38δ, control heart growth by promoting mTOR activity via phosphorylation and consequent proteasome degradation of mTOR inhibitor DEPTOR, extending our knowledge of cardiac hypertrophy regulation.
url	https://doi.org/10.1038/ncomms10477
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p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

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