The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up
Aim of the study: The purpose of the study was to monitor the effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up. Material and methods : Fifty six patients with symptomatic uterine fibroids qualified for surgical treatment were included in the prospe...
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doaj-dc95e77921954eb2a426e3431dfdbe9d2020-11-24T22:16:25ZengTermedia Publishing HouseMenopause Review1643-88762299-00382014-03-01131182110.5114/pm.2014.4109122421The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-upSławomir WoźniakPiotr SzkodziakPiotr CzuczwarEwa WoźniakowskaMaciej PaszkowskiPaweł MilartTomasz PaszkowskiAim of the study: The purpose of the study was to monitor the effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up. Material and methods : Fifty six patients with symptomatic uterine fibroids qualified for surgical treatment were included in the prospective observational study. All patients received preoperative oral UPA treatment for 3 months (1 × 5 mg). Patients that refused surgical treatment after UPA therapy were followed-up for the next 9 months. The volume of the intramural fibroid was estimated by TV-US using and integrated VOCAL 3D imaging program at baseline, after 3 months of UPA treatment and further at 3-months intervals. Results: Before UPA mean dominant fibroid volume was estimated to be 216.0 cm3 (38.4-768.2 cm 3 ) and decreased to 117.6 cm 3 (12.6-668.0 cm 3 ) after 3 months of UPA therapy. Mean percentage volume reduction was 45.6%. Mean hemoglobin level increased from an initial 10.1 g/dL (6.8-12.9 g/dL) to 12.6 g/dL (10.1-14.8) after 3 months of UPA therapy. At 12 months after initiating UPA treatment mean dominant fibroid volume decreased by 43.9%. In one third of followed-up patients the effect of 3 month UPA therapy persisted for the next 9 months. Conclusions : Three month UPA therapy decreases fibroid volume and improves hemoglobin level before planned surgical treatment. In one third of followed-up patients the effect of 3 month UPA therapy persisted for the next 9 months.http://www.termedia.pl/The-effect-of-ulipristal-acetate-treatment-on-symptomatic-uterine-fibroids-within-12-months-follow-up,4,22421,1,1.htmlulipristal acetate uterine fibroids ultrasound |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sławomir Woźniak Piotr Szkodziak Piotr Czuczwar Ewa Woźniakowska Maciej Paszkowski Paweł Milart Tomasz Paszkowski |
spellingShingle |
Sławomir Woźniak Piotr Szkodziak Piotr Czuczwar Ewa Woźniakowska Maciej Paszkowski Paweł Milart Tomasz Paszkowski The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up Menopause Review ulipristal acetate uterine fibroids ultrasound |
author_facet |
Sławomir Woźniak Piotr Szkodziak Piotr Czuczwar Ewa Woźniakowska Maciej Paszkowski Paweł Milart Tomasz Paszkowski |
author_sort |
Sławomir Woźniak |
title |
The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up |
title_short |
The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up |
title_full |
The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up |
title_fullStr |
The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up |
title_full_unstemmed |
The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up |
title_sort |
effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up |
publisher |
Termedia Publishing House |
series |
Menopause Review |
issn |
1643-8876 2299-0038 |
publishDate |
2014-03-01 |
description |
Aim of the study: The purpose of the study was to monitor the effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up.
Material and methods : Fifty six patients with symptomatic uterine fibroids qualified for surgical treatment were included in the prospective observational study. All patients received preoperative oral UPA treatment for 3 months (1 × 5 mg). Patients that refused surgical treatment after UPA therapy were followed-up for the next 9 months. The volume of the intramural fibroid was estimated by TV-US using and integrated VOCAL 3D imaging program at baseline, after 3 months of UPA treatment and further at 3-months intervals.
Results: Before UPA mean dominant fibroid volume was estimated to be 216.0 cm3 (38.4-768.2 cm 3 ) and decreased to 117.6 cm 3 (12.6-668.0 cm 3 ) after 3 months of UPA therapy. Mean percentage volume reduction was 45.6%. Mean hemoglobin level increased from an initial 10.1 g/dL (6.8-12.9 g/dL) to 12.6 g/dL (10.1-14.8) after 3 months of UPA therapy. At 12 months after initiating UPA treatment mean dominant fibroid volume decreased by 43.9%. In one third of followed-up patients the effect of 3 month UPA therapy persisted for the next 9 months.
Conclusions : Three month UPA therapy decreases fibroid volume and improves hemoglobin level before planned surgical treatment. In one third of followed-up patients the effect of 3 month UPA therapy persisted for the next 9 months. |
topic |
ulipristal acetate uterine fibroids ultrasound |
url |
http://www.termedia.pl/The-effect-of-ulipristal-acetate-treatment-on-symptomatic-uterine-fibroids-within-12-months-follow-up,4,22421,1,1.html |
work_keys_str_mv |
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