Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
Tropinone is an intermediate in the biosynthesis of tropane alkaloids. Here, the authors discovered the enzymes AbPYKS and AbCYP82M3, a non-canonical polyketide synthase and a cytochrome P450, that work sequentially to form tropinone from N-methyl-Δ1-pyrrolinium cation.
Main Authors: | Matthew A. Bedewitz, A. Daniel Jones, John C. D’Auria, Cornelius S. Barry |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-07671-3 |
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