Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in Mice
Recent studies have reported an increased incidence of inflammatory bowel disease (IBD) in patients with pulmonary diseases. Despite clinical and epidemiological studies of the interplay between colitis and asthma, the diseases' related underlying mechanisms remain unclear. In this study, we ev...
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00530/full |
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doaj-dca5fc4538e34fe5b2c84df03408d7102020-11-25T00:17:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00530386559Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in MiceKyoung-Hwa Jung0Dasom Shin1Sejun Kim2Daeun Min3Woogyeong Kim4Jinju Kim5Gihyun Lee6Hyunsu Bae7Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaDepartment of Korean Physiology, College of Pharmacy, Kyung Hee University, Seoul, South KoreaDepartment of Korean Physiology, College of Pharmacy, Kyung Hee University, Seoul, South KoreaCollege of Korean Medicine, Dongshin University, Naju, South KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaRecent studies have reported an increased incidence of inflammatory bowel disease (IBD) in patients with pulmonary diseases. Despite clinical and epidemiological studies of the interplay between colitis and asthma, the diseases' related underlying mechanisms remain unclear. In this study, we evaluated the development of colitis in a model of allergic airway inflammation. We revealed that intratracheal chronic ovalbumin (OVA) exposure induces colitis and allergic airway inflammation. Interestingly, induction of colitis was largely regulated by Th1, rather than Th2 responses, whereas allergic airway inflammation was primarily mediated by Th2 responses. Experiments in Tbx21 (T-bet) and Ifng (IFN-γ) deficient mice have confirmed that IFN-γ is a major mediator involved in OVA-induced colitis. These findings broaden current understanding of allergen induced colitis pathology and could play a role in the development of novel clinical treatment strategies for asthmatic patients who are at risk of developing colitis.https://www.frontiersin.org/article/10.3389/fimmu.2019.00530/fullallergy and immunologycolitisIFN-γovalbuminTh1 cells |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kyoung-Hwa Jung Dasom Shin Sejun Kim Daeun Min Woogyeong Kim Jinju Kim Gihyun Lee Hyunsu Bae |
| spellingShingle |
Kyoung-Hwa Jung Dasom Shin Sejun Kim Daeun Min Woogyeong Kim Jinju Kim Gihyun Lee Hyunsu Bae Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in Mice Frontiers in Immunology allergy and immunology colitis IFN-γ ovalbumin Th1 cells |
| author_facet |
Kyoung-Hwa Jung Dasom Shin Sejun Kim Daeun Min Woogyeong Kim Jinju Kim Gihyun Lee Hyunsu Bae |
| author_sort |
Kyoung-Hwa Jung |
| title |
Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in Mice |
| title_short |
Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in Mice |
| title_full |
Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in Mice |
| title_fullStr |
Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in Mice |
| title_full_unstemmed |
Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in Mice |
| title_sort |
intratracheal ovalbumin administration induces colitis through the ifn-γ pathway in mice |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2019-03-01 |
| description |
Recent studies have reported an increased incidence of inflammatory bowel disease (IBD) in patients with pulmonary diseases. Despite clinical and epidemiological studies of the interplay between colitis and asthma, the diseases' related underlying mechanisms remain unclear. In this study, we evaluated the development of colitis in a model of allergic airway inflammation. We revealed that intratracheal chronic ovalbumin (OVA) exposure induces colitis and allergic airway inflammation. Interestingly, induction of colitis was largely regulated by Th1, rather than Th2 responses, whereas allergic airway inflammation was primarily mediated by Th2 responses. Experiments in Tbx21 (T-bet) and Ifng (IFN-γ) deficient mice have confirmed that IFN-γ is a major mediator involved in OVA-induced colitis. These findings broaden current understanding of allergen induced colitis pathology and could play a role in the development of novel clinical treatment strategies for asthmatic patients who are at risk of developing colitis. |
| topic |
allergy and immunology colitis IFN-γ ovalbumin Th1 cells |
| url |
https://www.frontiersin.org/article/10.3389/fimmu.2019.00530/full |
| work_keys_str_mv |
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