The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities

The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities

Summary: To understand striatal function, it is essential to know the functional organization of the numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we activated terminals from ipsi- or contralateral primary somatosensory cortex (S1) or primary motor cortex...

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Main Authors: Yvonne Johansson, Gilad Silberberg
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719317607
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spelling doaj-dcaa7c8369e64de2ad63007767a8fda82020-11-24T22:15:12ZengElsevierCell Reports2211-12472020-01-0130411781194.e3The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell IdentitiesYvonne Johansson0Gilad Silberberg1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden; Corresponding authorDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden; Corresponding authorSummary: To understand striatal function, it is essential to know the functional organization of the numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we activated terminals from ipsi- or contralateral primary somatosensory cortex (S1) or primary motor cortex (M1), or thalamus while obtaining simultaneous whole-cell recordings from pairs or triplets of striatal medium spiny neurons (MSNs) and adjacent interneurons. Ipsilateral corticostriatal projections provided stronger excitation to fast-spiking interneurons (FSIs) than to MSNs and only sparse and weak excitation to low threshold-spiking interneurons (LTSIs) and cholinergic interneurons (ChINs). Projections from contralateral M1 evoked the strongest responses in LTSIs but none in ChINs, whereas thalamus provided the strongest excitation to ChINs but none to LTSIs. In addition, inputs varied in their glutamate receptor composition and their short-term plasticity. Our data revealed a highly selective organization of excitatory striatal afferents, which is determined by both pre- and postsynaptic neuronal identity. : Johansson and Silberberg map the organization of cortico- and thalamostriatal inputs onto five types of striatal neurons in terms of synaptic strength, short-term plasticity, and receptor composition. They find that the synaptic properties of 20 pathways are determined by both presynaptic region and postsynaptic cell type. Keywords: corticostriatal pathway, thalamostriatal pathway, striatum, multineuron patch-clamp, fast-spiking interneuron, cholingergic interneuron, low-threshold spiking interneuron, medium spiny neuron, IT tract/PT tract, NMDA to AMPA ratiohttp://www.sciencedirect.com/science/article/pii/S2211124719317607
collection DOAJ
language English
format Article
sources DOAJ
author Yvonne Johansson
Gilad Silberberg
spellingShingle Yvonne Johansson
Gilad Silberberg
The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities
Cell Reports
author_facet Yvonne Johansson
Gilad Silberberg
author_sort Yvonne Johansson
title The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities
title_short The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities
title_full The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities
title_fullStr The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities
title_full_unstemmed The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities
title_sort functional organization of cortical and thalamic inputs onto five types of striatal neurons is determined by source and target cell identities
publisher Elsevier
series Cell Reports
issn 2211-1247
publishDate 2020-01-01
description Summary: To understand striatal function, it is essential to know the functional organization of the numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we activated terminals from ipsi- or contralateral primary somatosensory cortex (S1) or primary motor cortex (M1), or thalamus while obtaining simultaneous whole-cell recordings from pairs or triplets of striatal medium spiny neurons (MSNs) and adjacent interneurons. Ipsilateral corticostriatal projections provided stronger excitation to fast-spiking interneurons (FSIs) than to MSNs and only sparse and weak excitation to low threshold-spiking interneurons (LTSIs) and cholinergic interneurons (ChINs). Projections from contralateral M1 evoked the strongest responses in LTSIs but none in ChINs, whereas thalamus provided the strongest excitation to ChINs but none to LTSIs. In addition, inputs varied in their glutamate receptor composition and their short-term plasticity. Our data revealed a highly selective organization of excitatory striatal afferents, which is determined by both pre- and postsynaptic neuronal identity. : Johansson and Silberberg map the organization of cortico- and thalamostriatal inputs onto five types of striatal neurons in terms of synaptic strength, short-term plasticity, and receptor composition. They find that the synaptic properties of 20 pathways are determined by both presynaptic region and postsynaptic cell type. Keywords: corticostriatal pathway, thalamostriatal pathway, striatum, multineuron patch-clamp, fast-spiking interneuron, cholingergic interneuron, low-threshold spiking interneuron, medium spiny neuron, IT tract/PT tract, NMDA to AMPA ratio
url http://www.sciencedirect.com/science/article/pii/S2211124719317607
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