Next-generation sequencing using microfluidic PCR enrichment for molecular autopsy

Next-generation sequencing using microfluidic PCR enrichment for molecular autopsy

Abstract Background We aimed to determine the mutation yield and clinical applicability of “molecular autopsy” following sudden arrhythmic death syndrome (SADS) by validating and utilizing low-cost high-throughput technologies: Fluidigm Access Array PCR-enrichment with Illumina HiSeq 2000 next gener...

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Bibliographic Details
Main Authors: Hariharan Raju, James S. Ware, Jonathan R. Skinner, Paula L. Hedley, Gavin Arno, Donald R. Love, Christian van der Werf, Jacob Tfelt-Hansen, Bo Gregers Winkel, Marta C. Cohen, Xinzhong Li, Shibu John, Sanjay Sharma, Steve Jeffery, Arthur A. M. Wilde, Michael Christiansen, Mary N. Sheppard, Elijah R. Behr
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cardiovascular Disorders
Subjects:
Molecular autopsy
Sudden arrhythmic death syndrome
Sudden unexplained death
Inherited cardiac conditions
Next generation sequencing
Online Access:http://link.springer.com/article/10.1186/s12872-019-1154-8

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