Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana

Bioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methyl...

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Main Authors:	Zeng Xu, Lei Huang, Xiao-Hong Chen, Xiao-Feng Zhu, Xiao-Jun Qian, Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li
Format:	Article
Language:	English
Published:	MDPI AG 2014-02-01
Series:	Molecules
Subjects:	Garcinia mangostana xanthones cytotoxic activities
Online Access:	http://www.mdpi.com/1420-3049/19/2/1820

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spelling	doaj-dcb6c1c8e6824f61ab7f3100d2612fd62020-11-25T00:00:24ZengMDPI AGMolecules1420-30492014-02-011921820182710.3390/molecules19021820molecules19021820Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostanaZeng Xu0Lei Huang1Xiao-Hong Chen2Xiao-Feng Zhu3Xiao-Jun Qian4Gong-Kan Feng5Wen-Jian Lan6Hou-Jin Li7School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaInstrumental Analysis and Research Center, Sun Yat-Sen University, Guangzhou 510275, ChinaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaSchool of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaBioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), together with the five known compounds garcinones C (3) and D (4), gartanin (5), xanthone I (6), and γ-mangostin (7). Their structures were elucidated primarily based on MS and NMR data. Compounds 1–7 showed significant cytotoxic activities against various human cancer cell lines.http://www.mdpi.com/1420-3049/19/2/1820Garcinia mangostanaxanthonescytotoxic activities
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zeng Xu Lei Huang Xiao-Hong Chen Xiao-Feng Zhu Xiao-Jun Qian Gong-Kan Feng Wen-Jian Lan Hou-Jin Li
spellingShingle	Zeng Xu Lei Huang Xiao-Hong Chen Xiao-Feng Zhu Xiao-Jun Qian Gong-Kan Feng Wen-Jian Lan Hou-Jin Li Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana Molecules Garcinia mangostana xanthones cytotoxic activities
author_facet	Zeng Xu Lei Huang Xiao-Hong Chen Xiao-Feng Zhu Xiao-Jun Qian Gong-Kan Feng Wen-Jian Lan Hou-Jin Li
author_sort	Zeng Xu
title	Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana
title_short	Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana
title_full	Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana
title_fullStr	Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana
title_full_unstemmed	Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana
title_sort	cytotoxic prenylated xanthones from the pericarps of garcinia mangostana
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2014-02-01
description	Bioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), together with the five known compounds garcinones C (3) and D (4), gartanin (5), xanthone I (6), and γ-mangostin (7). Their structures were elucidated primarily based on MS and NMR data. Compounds 1–7 showed significant cytotoxic activities against various human cancer cell lines.
topic	Garcinia mangostana xanthones cytotoxic activities
url	http://www.mdpi.com/1420-3049/19/2/1820
work_keys_str_mv	AT zengxu cytotoxicprenylatedxanthonesfromthepericarpsofgarciniamangostana AT leihuang cytotoxicprenylatedxanthonesfromthepericarpsofgarciniamangostana AT xiaohongchen cytotoxicprenylatedxanthonesfromthepericarpsofgarciniamangostana AT xiaofengzhu cytotoxicprenylatedxanthonesfromthepericarpsofgarciniamangostana AT xiaojunqian cytotoxicprenylatedxanthonesfromthepericarpsofgarciniamangostana AT gongkanfeng cytotoxicprenylatedxanthonesfromthepericarpsofgarciniamangostana AT wenjianlan cytotoxicprenylatedxanthonesfromthepericarpsofgarciniamangostana AT houjinli cytotoxicprenylatedxanthonesfromthepericarpsofgarciniamangostana
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Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana

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