Relationship of Vitamin D deficiency with Lipid metabolism, microinflammatory response and endothelial injury in obese children

• Main Authors: Ming-Zhen Li1, Rong Long2
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-06-01
• Series: Journal of Hainan Medical University
• Subjects: Obese children Vitamin D deficiency Lipid metabolism Micro-inflammatory response Endothelial injury
• Online Access: http://www.hnykdxxb.com/PDF/201711/29.pdf

Objective: To study the relationship of vitamin D deficiency with lipid metabolism, microinflammatory response and endothelial injury in obese children. Methods: a total of 68 cases of obese children who received examination in our hospital were chosen as obese group, 56 cases of overweight children who received examination in our hospital were chosen as overweight group, and 50 cases of normal children who received vaccination in our hospital were chosen as normal control group. The differences in peripheral blood 1,25-(OH)D3 content as well as serum contents of lipid metabolism, micro-inflammatory reaction and endothelial injury indexes were compared among three groups. Pearson test was used to evaluate the internal relationship between 1, 25-(OH)D3 and the degree of environmental disturbance in obese children. Results: 1,25-(OH) D3 contents in obese group and overweight group were lower than that in normal control group, and 1,25-(OH) D3 content in obese group was lower than that in overweight group. Serum contents of lipid metabolism indexes TC, TG and LDL-C in obese group and overweight group were higher than those in normal control group while HDL-C content was lower than that in normal control group; contents of micro-inflammation indexes CRP, IL-6 and TNF-α were higher than those in normal control group; serum content of endothelial injury index ET-1 was higher than that in normal control group while NO, CGRP and PGI2 contents were lower than those in normal control group; the changes in serum contents of above indexes in obese group were larger than those in overweight group. Conclusion: There is vitamin D deficiency in obese children, and the degree of deficiency is directly related to the degree of abnormal lipid metabolism, micro-inflammation and endothelial injury.