New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities

New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities

Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysi...

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Bibliographic Details
Main Authors: Ute Hentschel, Chris M. Ireland, Tanja Schirmeister, Jason Reppart, Gerhard Bringmann, Tobias A.M. Gulder, Tim S. Bugni, Verena Buback, Sheila M. Pimentel-Elardo
Format: Article
Language:English
Published: MDPI AG 2011-09-01
Series:Marine Drugs
Subjects:
tetromycin
anti-trypanosomal
protease inhibition
Streptomyces axinellae
marine sponge
Online Access:http://www.mdpi.com/1660-3397/9/10/1682/

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