Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infections
Nuclear factor kappa-light-chain enhancer of activated B-cells (NF-кB) is a pleiotropic transcription factor, which regulates processes of immune response and inflammation. NF-кB can undergo activation as a result of bacterial infections via Toll-like receptors (TLR), which recognize pathogen-associ...
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doaj-dccaca3c92e548369d7c2d631c7742242020-11-25T02:49:54ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932015-01-016996997710.5604/01.3001.0009.656701.3001.0009.6567Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infectionsJustyna Struzik0Lidia Szulc-Dąbrowska1Marek Niemiałtowski2Zakład Immunologii, Katedra Nauk Przedklinicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w WarszawieZakład Immunologii, Katedra Nauk Przedklinicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w WarszawieZakład Immunologii, Katedra Nauk Przedklinicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w WarszawieNuclear factor kappa-light-chain enhancer of activated B-cells (NF-кB) is a pleiotropic transcription factor, which regulates processes of immune response and inflammation. NF-кB can undergo activation as a result of bacterial infections via Toll-like receptors (TLR), which recognize pathogen-associated molecular patterns (PAMP), such as lipopolysaccharides (LPS). Stimulation of the cells results in phosphorylation of inhibitor кB (IкB) and the translocation of NF-кB to the nucleus, where the transcription of genes encoding molecules, such as proinflammatory cytokines and chemokines takes place. Activation of NF-кB undergoes modulation upon heat shock, which induces the expression of heat shock proteins (HSP). NF-кB, in turn, is involved in the regulation of transcription of genes encoding HSP, while members of HSP family are modulators of NF-кB activation, which occurs as a result bacterial infections and leads to the development of inflammation. HSP90 is a major chaperone, which is associated with IкB kinase (IKK) subunits. HSP90 inhibitors enable dissociation of such complexes, thus blocking NF-кB and inflammatory process during bacterial infections. HSP72 and HSP70, in turn, modulate the expression of NF-кB controlled genes during sepsis and play a protective role, whereas exogenous HSP70 may enhance the inflammatory response. Bacterial HSP, such as HSP60 of Chlamydia pneumophila and Helicobacter pylori, or GroL of Porphyromonas gingivalis, as well as HSP65 and HSP70 of Mycobacterium tuberculosis and DnaK of Francisella tularensis activate NF-κB and inflammation. Knowledge of these interactions is extremely helpful in the development of therapeutic strategies. http://phmd.pl/gicid/01.3001.0009.6567Bacterial Infectionstranscription factor NF-кBheat shock proteinszakażenia bakteryjneczynnik transkrypcyjny NF-кBbiałka szoku cieplnego |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Justyna Struzik Lidia Szulc-Dąbrowska Marek Niemiałtowski |
spellingShingle |
Justyna Struzik Lidia Szulc-Dąbrowska Marek Niemiałtowski Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infections Postępy Higieny i Medycyny Doświadczalnej Bacterial Infections transcription factor NF-кB heat shock proteins zakażenia bakteryjne czynnik transkrypcyjny NF-кB białka szoku cieplnego |
author_facet |
Justyna Struzik Lidia Szulc-Dąbrowska Marek Niemiałtowski |
author_sort |
Justyna Struzik |
title |
Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infections |
title_short |
Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infections |
title_full |
Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infections |
title_fullStr |
Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infections |
title_full_unstemmed |
Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infections |
title_sort |
participation of heat shock proteins in modulation of nf-кb transcription factor activation during bacterial infections |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2015-01-01 |
description |
Nuclear factor kappa-light-chain enhancer of activated B-cells (NF-кB) is a pleiotropic transcription factor, which regulates processes of immune response and inflammation. NF-кB can undergo activation as a result of bacterial infections via Toll-like receptors (TLR), which recognize pathogen-associated molecular patterns (PAMP), such as lipopolysaccharides (LPS). Stimulation of the cells results in phosphorylation of inhibitor кB (IкB) and the translocation of NF-кB to the nucleus, where the transcription of genes encoding molecules, such as proinflammatory cytokines and chemokines takes place. Activation of NF-кB undergoes modulation upon heat shock, which induces the expression of heat shock proteins (HSP). NF-кB, in turn, is involved in the regulation of transcription of genes encoding HSP, while members of HSP family are modulators of NF-кB activation, which occurs as a result bacterial infections and leads to the development of inflammation. HSP90 is a major chaperone, which is associated with IкB kinase (IKK) subunits. HSP90 inhibitors enable dissociation of such complexes, thus blocking NF-кB and inflammatory process during bacterial infections. HSP72 and HSP70, in turn, modulate the expression of NF-кB controlled genes during sepsis and play a protective role, whereas exogenous HSP70 may enhance the inflammatory response. Bacterial HSP, such as HSP60 of Chlamydia pneumophila and Helicobacter pylori, or GroL of Porphyromonas gingivalis, as well as HSP65 and HSP70 of Mycobacterium tuberculosis and DnaK of Francisella tularensis activate NF-κB and inflammation. Knowledge of these interactions is extremely helpful in the development of therapeutic strategies.
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topic |
Bacterial Infections transcription factor NF-кB heat shock proteins zakażenia bakteryjne czynnik transkrypcyjny NF-кB białka szoku cieplnego |
url |
http://phmd.pl/gicid/01.3001.0009.6567 |
work_keys_str_mv |
AT justynastruzik participationofheatshockproteinsinmodulationofnfkbtranscriptionfactoractivationduringbacterialinfections AT lidiaszulcdabrowska participationofheatshockproteinsinmodulationofnfkbtranscriptionfactoractivationduringbacterialinfections AT marekniemiałtowski participationofheatshockproteinsinmodulationofnfkbtranscriptionfactoractivationduringbacterialinfections |
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1724741546771742720 |