Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance
Metabolically heathy obesity is characterised by the presence of obesity in the absence of metabolic disturbances. The aim of our study was to analyse pro-inflammatory, nitro-oxidative stress, and insulin-resistance (IR) markers in metabolically healthy morbidly obese (MHMO) with respect to metaboli...
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doaj-dcd406123d3a45e1b082f719a6c5d2882020-11-24T22:20:07ZengMDPI AGNutrients2072-66432018-09-01109119910.3390/nu10091199nu10091199Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin ResistanceAdriana Florinela Cӑtoi0Alina Elena Pârvu1Andra Diana Andreicuț2Aurel Mironiuc3Alexandra Crӑciun4Cornel Cӑtoi5Ioana Delia Pop6Department of Pathophysiology, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, Cluj-Napoca 400012, RomaniaDepartment of Pathophysiology, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, Cluj-Napoca 400012, RomaniaDepartment of Pathophysiology, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, Cluj-Napoca 400012, RomaniaSecond Surgical Clinic, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy Cluj-Napoca 400012, RomaniaDepartment of Biochemistry, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, Cluj-Napoca 400012, RomaniaDepartment of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca 400012, RomaniaDepartment of Exact Sciences, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca 400012, RomaniaMetabolically heathy obesity is characterised by the presence of obesity in the absence of metabolic disturbances. The aim of our study was to analyse pro-inflammatory, nitro-oxidative stress, and insulin-resistance (IR) markers in metabolically healthy morbidly obese (MHMO) with respect to metabolically unhealthy morbidly obese (MUHMO) with metabolic syndrome (MS) and to identify the potential predictors of MS in the MHMO group. Two groups of MHMO and MUHMO with MS were analysed. We evaluated serum high sensitivity C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), chemerin, nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), fasting blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR.) MHMO have similar hsCRP and TNF-α values as the MUHMO with MS, while chemerin was significantly lower in MHMO. NOx was higher in MUHMO with MS patients, while no difference regarding TOS and TAR was found between the two groups. HOMA-IR and insulin values were lower in MHMO as compared to the MUHMO with MS group. Insulin, HOMA-IR, and chemerin were identified predictors of MS in MHMO. In conclusion, MHMO and MUHMO display similarities and differences in terms of chronic inflammation, nitro-oxidative stress, and IR. Markers of IR and chemerin are possible predictors of MS in MHMO.http://www.mdpi.com/2072-6643/10/9/1199metabolically healthy morbidly obesemetabolically unhealthy morbidly obesemetabolic syndromechronic inflammationnitro-oxidative stressinsulin-resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adriana Florinela Cӑtoi Alina Elena Pârvu Andra Diana Andreicuț Aurel Mironiuc Alexandra Crӑciun Cornel Cӑtoi Ioana Delia Pop |
spellingShingle |
Adriana Florinela Cӑtoi Alina Elena Pârvu Andra Diana Andreicuț Aurel Mironiuc Alexandra Crӑciun Cornel Cӑtoi Ioana Delia Pop Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance Nutrients metabolically healthy morbidly obese metabolically unhealthy morbidly obese metabolic syndrome chronic inflammation nitro-oxidative stress insulin-resistance |
author_facet |
Adriana Florinela Cӑtoi Alina Elena Pârvu Andra Diana Andreicuț Aurel Mironiuc Alexandra Crӑciun Cornel Cӑtoi Ioana Delia Pop |
author_sort |
Adriana Florinela Cӑtoi |
title |
Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance |
title_short |
Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance |
title_full |
Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance |
title_fullStr |
Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance |
title_full_unstemmed |
Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance |
title_sort |
metabolically healthy versus unhealthy morbidly obese: chronic inflammation, nitro-oxidative stress, and insulin resistance |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-09-01 |
description |
Metabolically heathy obesity is characterised by the presence of obesity in the absence of metabolic disturbances. The aim of our study was to analyse pro-inflammatory, nitro-oxidative stress, and insulin-resistance (IR) markers in metabolically healthy morbidly obese (MHMO) with respect to metabolically unhealthy morbidly obese (MUHMO) with metabolic syndrome (MS) and to identify the potential predictors of MS in the MHMO group. Two groups of MHMO and MUHMO with MS were analysed. We evaluated serum high sensitivity C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), chemerin, nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), fasting blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR.) MHMO have similar hsCRP and TNF-α values as the MUHMO with MS, while chemerin was significantly lower in MHMO. NOx was higher in MUHMO with MS patients, while no difference regarding TOS and TAR was found between the two groups. HOMA-IR and insulin values were lower in MHMO as compared to the MUHMO with MS group. Insulin, HOMA-IR, and chemerin were identified predictors of MS in MHMO. In conclusion, MHMO and MUHMO display similarities and differences in terms of chronic inflammation, nitro-oxidative stress, and IR. Markers of IR and chemerin are possible predictors of MS in MHMO. |
topic |
metabolically healthy morbidly obese metabolically unhealthy morbidly obese metabolic syndrome chronic inflammation nitro-oxidative stress insulin-resistance |
url |
http://www.mdpi.com/2072-6643/10/9/1199 |
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