A case of SRSF2 mutation in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is characterized by extremely variable clinical course indicating substantial differences in the biology of the disease. Molecular characterization provides new insights useful for treatment decision making. We report on a patient diagnosed with CLL, whose disease...
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Elsevier
2016-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048915300261 |
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doaj-dcdcd69844d54b0e985c87badbe134202020-11-24T23:54:04ZengElsevierLeukemia Research Reports2213-04892016-01-016C111410.1016/j.lrr.2016.03.001A case of SRSF2 mutation in chronic lymphocytic leukemiaEduardo Garza0Giovanni Del Poeta1Carmen Martínez-Losada2Gianfranco Catalano3Loredana Borgia4Maria Liliana Piredda5Emiliano Fabiani6Valter Gattei7Francesco Lo-Coco8Nélida I. Noguera9Laboratory of Neuro-Oncoematology, Santa Lucia Foundation, Rome, ItalyDepartment of Biomedicina e Prevenzione, “Tor Vergata” University, Rome, ItalyLaboratory of Neuro-Oncoematology, Santa Lucia Foundation, Rome, ItalyDepartment of Biomedicina e Prevenzione, “Tor Vergata” University, Rome, ItalyLaboratory of Neuro-Oncoematology, Santa Lucia Foundation, Rome, ItalyLaboratory of Neuro-Oncoematology, Santa Lucia Foundation, Rome, ItalyDepartment of Hematology, Universita’Cattolica S. Cuore, Rome, ItalyClinical & Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, ItalyLaboratory of Neuro-Oncoematology, Santa Lucia Foundation, Rome, ItalyLaboratory of Neuro-Oncoematology, Santa Lucia Foundation, Rome, ItalyChronic lymphocytic leukemia (CLL) is characterized by extremely variable clinical course indicating substantial differences in the biology of the disease. Molecular characterization provides new insights useful for treatment decision making. We report on a patient diagnosed with CLL, whose disease was characterized by episodes of rapid progression and disease stabilization, and in which a SRSF2 gene mutation was identified in the absence of other commonly known mutations of CLL. To the best of our knowledge this is the first case of SRSF2 gene mutation ever reported in CLL.http://www.sciencedirect.com/science/article/pii/S2213048915300261Genetic analysisChronic lymphocytic leukemiaClinical aspectSRSF2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Eduardo Garza Giovanni Del Poeta Carmen Martínez-Losada Gianfranco Catalano Loredana Borgia Maria Liliana Piredda Emiliano Fabiani Valter Gattei Francesco Lo-Coco Nélida I. Noguera |
| spellingShingle |
Eduardo Garza Giovanni Del Poeta Carmen Martínez-Losada Gianfranco Catalano Loredana Borgia Maria Liliana Piredda Emiliano Fabiani Valter Gattei Francesco Lo-Coco Nélida I. Noguera A case of SRSF2 mutation in chronic lymphocytic leukemia Leukemia Research Reports Genetic analysis Chronic lymphocytic leukemia Clinical aspect SRSF2 |
| author_facet |
Eduardo Garza Giovanni Del Poeta Carmen Martínez-Losada Gianfranco Catalano Loredana Borgia Maria Liliana Piredda Emiliano Fabiani Valter Gattei Francesco Lo-Coco Nélida I. Noguera |
| author_sort |
Eduardo Garza |
| title |
A case of SRSF2 mutation in chronic lymphocytic leukemia |
| title_short |
A case of SRSF2 mutation in chronic lymphocytic leukemia |
| title_full |
A case of SRSF2 mutation in chronic lymphocytic leukemia |
| title_fullStr |
A case of SRSF2 mutation in chronic lymphocytic leukemia |
| title_full_unstemmed |
A case of SRSF2 mutation in chronic lymphocytic leukemia |
| title_sort |
case of srsf2 mutation in chronic lymphocytic leukemia |
| publisher |
Elsevier |
| series |
Leukemia Research Reports |
| issn |
2213-0489 |
| publishDate |
2016-01-01 |
| description |
Chronic lymphocytic leukemia (CLL) is characterized by extremely variable clinical course indicating substantial differences in the biology of the disease. Molecular characterization provides new insights useful for treatment decision making. We report on a patient diagnosed with CLL, whose disease was characterized by episodes of rapid progression and disease stabilization, and in which a SRSF2 gene mutation was identified in the absence of other commonly known mutations of CLL. To the best of our knowledge this is the first case of SRSF2 gene mutation ever reported in CLL. |
| topic |
Genetic analysis Chronic lymphocytic leukemia Clinical aspect SRSF2 |
| url |
http://www.sciencedirect.com/science/article/pii/S2213048915300261 |
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