Low, but Physiological, Concentration of GLP-1 Stimulates Insulin Secretion Independent of the cAMP-Dependent Protein Kinase Pathway
Glucagon-like peptide-1 (GLP-1) induces pancreatic insulin secretion via the cAMP-dependent protein kinase (PKA) pathway. However, the GLP-1 concentration used in the previous in vitro experiments was far from the in vivo concentrations. Alteration of plasma GLP-1 concentration at pM order lowers bl...
Main Authors: | Makoto Shigeto, Masashi Katsura, Masafumi Matsuda, Seitaro Ohkuma, Kohei Kaku |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2008-01-01
|
Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319313349 |
Similar Items
-
First Phase of Glucose-Stimulated Insulin Secretion From MIN 6 Cells Does Not Always Require Extracellular Calcium Influx
by: Shigeto Makoto, et al.
Published: (2006-01-01) -
Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Chronic Nicotine Treatment Upregulates L-Type High Voltage-Gated Calcium Channels
by: Masashi Katsura, et al.
Published: (2005-01-01) -
CXCL14 Inhibits Insulin Secretion Independently of CXCR4 or CXCR7 Receptor Activation or cAMP Inhibition
by: Patricio Atanes, et al.
Published: (2019-03-01) -
Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10.
by: Tara A Schwetz, et al.
Published: (2014-01-01) -
New concept of the glucagon‐like peptide‐1 signaling pathway on pancreatic insulin secretion
by: Kohei Kaku
Published: (2020-03-01)