Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)
Anaphylactoid shock is a fatal hypersensitivity response caused by non-IgE mediated mast cell activation. These reactions are mediated by a family of G protein-coupled receptors (GPCRs) known as Mas related GPCRX2 (MRGPRX2). Several US FDA approved drugs which are used in day to day life have been r...
Main Authors: | Mukesh Kumar, Kailash Singh, Karthi Duraisamy, Ahmed A. Allam, Jamaan Ajarem, Billy Kwok Chong CHOW |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-02-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/5/1028 |
Similar Items
-
MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities
by: Marc A. Lafleur, et al.
Published: (2020-01-01) -
MRGPRX2 and Adverse Drug Reactions
by: Benjamin D. McNeil
Published: (2021-08-01) -
Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions
by: Grzegorz Porebski, et al.
Published: (2018-12-01) -
MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol
by: Feng Yuan, et al.
Published: (2021-05-01) -
Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones
by: Jessy Elst, et al.
Published: (2021-07-01)