Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)

Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)

Anaphylactoid shock is a fatal hypersensitivity response caused by non-IgE mediated mast cell activation. These reactions are mediated by a family of G protein-coupled receptors (GPCRs) known as Mas related GPCRX2 (MRGPRX2). Several US FDA approved drugs which are used in day to day life have been r...

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Bibliographic Details
Main Authors: Mukesh Kumar, Kailash Singh, Karthi Duraisamy, Ahmed A. Allam, Jamaan Ajarem, Billy Kwok Chong CHOW
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
anaphylactoid shock
mast cells
allergy
mrgprx2
Online Access:https://www.mdpi.com/1420-3049/25/5/1028

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