The conserved ADAMTS-like protein lonely heart mediates matrix formation and cardiac tissue integrity.

The conserved ADAMTS-like protein lonely heart mediates matrix formation and cardiac tissue integrity.

Here we report on the identification and functional characterization of the ADAMTS-like homolog lonely heart (loh) in Drosophila melanogaster. Loh displays all hallmarks of ADAMTSL proteins including several thrombospondin type 1 repeats (TSR1), and acts in concert with the collagen Pericardin (Prc)...

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Bibliographic Details
Main Authors: Maik Drechsler, Ariane C Schmidt, Heiko Meyer, Achim Paululat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3708815?pdf=render

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