A molecular quantitative trait locus map for osteoarthritis
Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potenti...
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2021-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-21593-7 |
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doaj-dcec7e1450ec48c58e6b36aa6fd093ff2021-03-11T11:31:42ZengNature Publishing GroupNature Communications2041-17232021-02-0112111110.1038/s41467-021-21593-7A molecular quantitative trait locus map for osteoarthritisJulia Steinberg0Lorraine Southam1Theodoros I. Roumeliotis2Matthew J. Clark3Raveen L. Jayasuriya4Diane Swift5Karan M. Shah6Natalie C. Butterfield7Roger A. Brooks8Andrew W. McCaskie9J. H. Duncan Bassett10Graham R. Williams11Jyoti S. Choudhary12J. Mark Wilkinson13Eleftheria Zeggini14Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthInstitute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthWellcome Sanger InstituteDepartment of Oncology and Metabolism, University of SheffieldDepartment of Oncology and Metabolism, University of SheffieldDepartment of Oncology and Metabolism, University of SheffieldDepartment of Oncology and Metabolism, University of SheffieldMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonDivision of Trauma & Orthopaedic Surgery, Department of Surgery, University of CambridgeDivision of Trauma & Orthopaedic Surgery, Department of Surgery, University of CambridgeMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonWellcome Sanger InstituteDepartment of Oncology and Metabolism, University of SheffieldInstitute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthUnderstanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potential drug treatments.https://doi.org/10.1038/s41467-021-21593-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julia Steinberg Lorraine Southam Theodoros I. Roumeliotis Matthew J. Clark Raveen L. Jayasuriya Diane Swift Karan M. Shah Natalie C. Butterfield Roger A. Brooks Andrew W. McCaskie J. H. Duncan Bassett Graham R. Williams Jyoti S. Choudhary J. Mark Wilkinson Eleftheria Zeggini |
spellingShingle |
Julia Steinberg Lorraine Southam Theodoros I. Roumeliotis Matthew J. Clark Raveen L. Jayasuriya Diane Swift Karan M. Shah Natalie C. Butterfield Roger A. Brooks Andrew W. McCaskie J. H. Duncan Bassett Graham R. Williams Jyoti S. Choudhary J. Mark Wilkinson Eleftheria Zeggini A molecular quantitative trait locus map for osteoarthritis Nature Communications |
author_facet |
Julia Steinberg Lorraine Southam Theodoros I. Roumeliotis Matthew J. Clark Raveen L. Jayasuriya Diane Swift Karan M. Shah Natalie C. Butterfield Roger A. Brooks Andrew W. McCaskie J. H. Duncan Bassett Graham R. Williams Jyoti S. Choudhary J. Mark Wilkinson Eleftheria Zeggini |
author_sort |
Julia Steinberg |
title |
A molecular quantitative trait locus map for osteoarthritis |
title_short |
A molecular quantitative trait locus map for osteoarthritis |
title_full |
A molecular quantitative trait locus map for osteoarthritis |
title_fullStr |
A molecular quantitative trait locus map for osteoarthritis |
title_full_unstemmed |
A molecular quantitative trait locus map for osteoarthritis |
title_sort |
molecular quantitative trait locus map for osteoarthritis |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-02-01 |
description |
Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potential drug treatments. |
url |
https://doi.org/10.1038/s41467-021-21593-7 |
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