A molecular quantitative trait locus map for osteoarthritis

A molecular quantitative trait locus map for osteoarthritis

Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potenti...

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Main Authors: Julia Steinberg, Lorraine Southam, Theodoros I. Roumeliotis, Matthew J. Clark, Raveen L. Jayasuriya, Diane Swift, Karan M. Shah, Natalie C. Butterfield, Roger A. Brooks, Andrew W. McCaskie, J. H. Duncan Bassett, Graham R. Williams, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21593-7
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spelling doaj-dcec7e1450ec48c58e6b36aa6fd093ff2021-03-11T11:31:42ZengNature Publishing GroupNature Communications2041-17232021-02-0112111110.1038/s41467-021-21593-7A molecular quantitative trait locus map for osteoarthritisJulia Steinberg0Lorraine Southam1Theodoros I. Roumeliotis2Matthew J. Clark3Raveen L. Jayasuriya4Diane Swift5Karan M. Shah6Natalie C. Butterfield7Roger A. Brooks8Andrew W. McCaskie9J. H. Duncan Bassett10Graham R. Williams11Jyoti S. Choudhary12J. Mark Wilkinson13Eleftheria Zeggini14Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthInstitute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthWellcome Sanger InstituteDepartment of Oncology and Metabolism, University of SheffieldDepartment of Oncology and Metabolism, University of SheffieldDepartment of Oncology and Metabolism, University of SheffieldDepartment of Oncology and Metabolism, University of SheffieldMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonDivision of Trauma & Orthopaedic Surgery, Department of Surgery, University of CambridgeDivision of Trauma & Orthopaedic Surgery, Department of Surgery, University of CambridgeMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonWellcome Sanger InstituteDepartment of Oncology and Metabolism, University of SheffieldInstitute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthUnderstanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potential drug treatments.https://doi.org/10.1038/s41467-021-21593-7
collection DOAJ
language English
format Article
sources DOAJ
author Julia Steinberg
Lorraine Southam
Theodoros I. Roumeliotis
Matthew J. Clark
Raveen L. Jayasuriya
Diane Swift
Karan M. Shah
Natalie C. Butterfield
Roger A. Brooks
Andrew W. McCaskie
J. H. Duncan Bassett
Graham R. Williams
Jyoti S. Choudhary
J. Mark Wilkinson
Eleftheria Zeggini
spellingShingle Julia Steinberg
Lorraine Southam
Theodoros I. Roumeliotis
Matthew J. Clark
Raveen L. Jayasuriya
Diane Swift
Karan M. Shah
Natalie C. Butterfield
Roger A. Brooks
Andrew W. McCaskie
J. H. Duncan Bassett
Graham R. Williams
Jyoti S. Choudhary
J. Mark Wilkinson
Eleftheria Zeggini
A molecular quantitative trait locus map for osteoarthritis
Nature Communications
author_facet Julia Steinberg
Lorraine Southam
Theodoros I. Roumeliotis
Matthew J. Clark
Raveen L. Jayasuriya
Diane Swift
Karan M. Shah
Natalie C. Butterfield
Roger A. Brooks
Andrew W. McCaskie
J. H. Duncan Bassett
Graham R. Williams
Jyoti S. Choudhary
J. Mark Wilkinson
Eleftheria Zeggini
author_sort Julia Steinberg
title A molecular quantitative trait locus map for osteoarthritis
title_short A molecular quantitative trait locus map for osteoarthritis
title_full A molecular quantitative trait locus map for osteoarthritis
title_fullStr A molecular quantitative trait locus map for osteoarthritis
title_full_unstemmed A molecular quantitative trait locus map for osteoarthritis
title_sort molecular quantitative trait locus map for osteoarthritis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potential drug treatments.
url https://doi.org/10.1038/s41467-021-21593-7
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