Shape-Memory Nanofiber Meshes with Programmable Cell Orientation
In this work we report the rational design of temperature-responsive nanofiber meshes with shape-memory properties. Meshes were fabricated by electrospinning poly(ε-caprolactone) (PCL)-based polyurethane with varying ratios of soft (PCL diol) and hard [hexamethylene diisocyanate (HDI)/1,...
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doaj-dcf1b50f45704e74b26150e429ca28612020-11-24T21:54:42ZengMDPI AGFibers2079-64392019-03-01732010.3390/fib7030020fib7030020Shape-Memory Nanofiber Meshes with Programmable Cell OrientationEri Niiyama0Kanta Tanabe1Koichiro Uto2Akihiko Kikuchi3Mitsuhiro Ebara4International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, JapanInternational Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, JapanInternational Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, JapanDepartment of Materials Science and Technology, Tokyo University of Science, Katsushika, Tokyo 125-8585, JapanInternational Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, JapanIn this work we report the rational design of temperature-responsive nanofiber meshes with shape-memory properties. Meshes were fabricated by electrospinning poly(ε-caprolactone) (PCL)-based polyurethane with varying ratios of soft (PCL diol) and hard [hexamethylene diisocyanate (HDI)/1,4-butanediol (BD)] segments. By altering the PCL diol:HDI:BD molar ratio both shape-memory properties and mechanical properties could be readily turned and modulated. Though mechanical properties improved by increasing the hard to soft segment ratio, optimal shape-memory properties were obtained using a PCL/HDI/BD molar ratio of 1:4:3. Microscopically, the original nanofibrous structure could be deformed into and maintained in a temporary shape and later recover its original structure upon reheating. Even when deformed by 400%, a recovery rate of >89% was observed. Implementation of these shape memory nanofiber meshes as cell culture platforms revealed the unique ability to alter human mesenchymal stem cell alignment and orientation. Due to their biocompatible nature, temperature-responsivity, and ability to control cell alignment, we believe that these meshes may demonstrate great promise as biomedical applications.http://www.mdpi.com/2079-6439/7/3/20shape memory nanofibershape memory polymerpoly(ε-caprolactone)melting temperaturecell orientationpolyurethane |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eri Niiyama Kanta Tanabe Koichiro Uto Akihiko Kikuchi Mitsuhiro Ebara |
spellingShingle |
Eri Niiyama Kanta Tanabe Koichiro Uto Akihiko Kikuchi Mitsuhiro Ebara Shape-Memory Nanofiber Meshes with Programmable Cell Orientation Fibers shape memory nanofiber shape memory polymer poly(ε-caprolactone) melting temperature cell orientation polyurethane |
author_facet |
Eri Niiyama Kanta Tanabe Koichiro Uto Akihiko Kikuchi Mitsuhiro Ebara |
author_sort |
Eri Niiyama |
title |
Shape-Memory Nanofiber Meshes with Programmable Cell Orientation |
title_short |
Shape-Memory Nanofiber Meshes with Programmable Cell Orientation |
title_full |
Shape-Memory Nanofiber Meshes with Programmable Cell Orientation |
title_fullStr |
Shape-Memory Nanofiber Meshes with Programmable Cell Orientation |
title_full_unstemmed |
Shape-Memory Nanofiber Meshes with Programmable Cell Orientation |
title_sort |
shape-memory nanofiber meshes with programmable cell orientation |
publisher |
MDPI AG |
series |
Fibers |
issn |
2079-6439 |
publishDate |
2019-03-01 |
description |
In this work we report the rational design of temperature-responsive nanofiber meshes with shape-memory properties. Meshes were fabricated by electrospinning poly(ε-caprolactone) (PCL)-based polyurethane with varying ratios of soft (PCL diol) and hard [hexamethylene diisocyanate (HDI)/1,4-butanediol (BD)] segments. By altering the PCL diol:HDI:BD molar ratio both shape-memory properties and mechanical properties could be readily turned and modulated. Though mechanical properties improved by increasing the hard to soft segment ratio, optimal shape-memory properties were obtained using a PCL/HDI/BD molar ratio of 1:4:3. Microscopically, the original nanofibrous structure could be deformed into and maintained in a temporary shape and later recover its original structure upon reheating. Even when deformed by 400%, a recovery rate of >89% was observed. Implementation of these shape memory nanofiber meshes as cell culture platforms revealed the unique ability to alter human mesenchymal stem cell alignment and orientation. Due to their biocompatible nature, temperature-responsivity, and ability to control cell alignment, we believe that these meshes may demonstrate great promise as biomedical applications. |
topic |
shape memory nanofiber shape memory polymer poly(ε-caprolactone) melting temperature cell orientation polyurethane |
url |
http://www.mdpi.com/2079-6439/7/3/20 |
work_keys_str_mv |
AT eriniiyama shapememorynanofibermesheswithprogrammablecellorientation AT kantatanabe shapememorynanofibermesheswithprogrammablecellorientation AT koichirouto shapememorynanofibermesheswithprogrammablecellorientation AT akihikokikuchi shapememorynanofibermesheswithprogrammablecellorientation AT mitsuhiroebara shapememorynanofibermesheswithprogrammablecellorientation |
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1725866245052432384 |