Olaparib-mediated enhancement of 5-fluorouracil cytotoxicity in mismatch repair deficient colorectal cancer cells

Olaparib-mediated enhancement of 5-fluorouracil cytotoxicity in mismatch repair deficient colorectal cancer cells

Abstract Background The advances in colorectal cancer (CRC) treatment include the identification of deficiencies in Mismatch Repair (MMR) pathway to predict the benefit of adjuvant 5-fluorouracil (5-FU) and oxaliplatin for stage II CRC and immunotherapy. Defective MMR contributes to chemoresistance...

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Main Authors: Helena de Castro e Gloria, Laura Jesuíno Nogueira, Patrícia Bencke Grudzinski, Paola Victória da Costa Ghignatti, Temenouga Nikolova Guecheva, Natalia Motta Leguisamo, Jenifer Saffi
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Mismatch repair
5-fluorouracil
PARP
Olaparib
Online Access:https://doi.org/10.1186/s12885-021-08188-7

Internet

https://doi.org/10.1186/s12885-021-08188-7

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