A Case of Blistering Eruptions in Systemic Lupus Erythematosus

• Main Authors: Sarojini Raman, Abhimanyu Grover, Prasant Padhan, Urmila Senapati
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2019-09-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: autoimmunity; direct; fluorescent antibody technique; skin
• Online Access: https://jcdr.net/articles/PDF/13155/42338_CE[Ra1]_F(KM)_PF1(TR_PoG_OM)_PN(SL).pdf

Cutaneous vesiculobullous lesions have a wide aetiological spectrum ranging from autoimmunity to medications and infections. Systemic Lupus Erythematosus (SLE) is one of most frequent autoimmune diseases with its cutaneous form being very uncommonly encountered. We report a case of Bullous Systemic Lupus Erythematosus (BSLE). Patient presented with fever, arthalgia and widespread blistering eruptions on face, neck and upper chest wall. Skin biopsy revealed subepidermal bulla and Direct Immunofluorescence (DIF) showed deposition of IgG, IgA, IgM, C3, C1q at the dermoepidermal junction. On treatment lesions healed rapidly. So proper clinical acumina is essential for diagnosis and management of such cases excluding the differentials.