Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer
Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of...
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American Society for Microbiology
2019-01-01
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Online Access: | https://doi.org/10.1128/mBio.02626-18 |
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doaj-dd1247a1423a4e72a1a4ff94c29db91b2021-07-02T02:39:16ZengAmerican Society for MicrobiologymBio2150-75112019-01-01101e02626-1810.1128/mBio.02626-18Going Viral: a Novel Role for Bacteriophage in Colorectal CancerScott A. HandleySuzanne DevkotaMicrobiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases.Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract.https://doi.org/10.1128/mBio.02626-18bacteriophagecolorectal cancermicrobiomevirome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Scott A. Handley Suzanne Devkota |
spellingShingle |
Scott A. Handley Suzanne Devkota Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer mBio bacteriophage colorectal cancer microbiome virome |
author_facet |
Scott A. Handley Suzanne Devkota |
author_sort |
Scott A. Handley |
title |
Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer |
title_short |
Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer |
title_full |
Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer |
title_fullStr |
Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer |
title_full_unstemmed |
Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer |
title_sort |
going viral: a novel role for bacteriophage in colorectal cancer |
publisher |
American Society for Microbiology |
series |
mBio |
issn |
2150-7511 |
publishDate |
2019-01-01 |
description |
Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases.Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract. |
topic |
bacteriophage colorectal cancer microbiome virome |
url |
https://doi.org/10.1128/mBio.02626-18 |
work_keys_str_mv |
AT scottahandley goingviralanovelroleforbacteriophageincolorectalcancer AT suzannedevkota goingviralanovelroleforbacteriophageincolorectalcancer |
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1721343078188449792 |