Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents

A novel series of 2-Chloroquinoline nucleus clubbed with the pyrazole ring has been synthesized and screened for antibacterial and antifungal activity. The results obtained were promising against both bacterial and fungal strains. Among the series, compound MB-N was found moderately active against...

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Main Authors:	Pankaj B. Miniyar, Mahesh A. Barmade, Anand A. Mahajan
Format:	Article
Language:	English
Published:	Elsevier 2015-11-01
Series:	Journal of Saudi Chemical Society
Subjects:	Quinoline Pyrazole Antibacterial Antifungal
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319610313001348

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spelling	doaj-dd15c85d734e499585aedc52032027a02020-11-25T01:57:23ZengElsevierJournal of Saudi Chemical Society1319-61032015-11-0119665566010.1016/j.jscs.2013.12.004Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agentsPankaj B. MiniyarMahesh A. BarmadeAnand A. MahajanA novel series of 2-Chloroquinoline nucleus clubbed with the pyrazole ring has been synthesized and screened for antibacterial and antifungal activity. The results obtained were promising against both bacterial and fungal strains. Among the series, compound MB-N was found moderately active against Aspergillus fumigatus, Penicillium notatum and Bacillus subtilis having MIC 48, 46 and 44 μg/ml, respectively whereas compound MB-A was found active against P. notatum, B. subtilis and Escherichia coli having MIC 57, 54 and 43 μg/ml, respectively as compared to standard.http://www.sciencedirect.com/science/article/pii/S1319610313001348QuinolinePyrazoleAntibacterialAntifungal
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pankaj B. Miniyar Mahesh A. Barmade Anand A. Mahajan
spellingShingle	Pankaj B. Miniyar Mahesh A. Barmade Anand A. Mahajan Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents Journal of Saudi Chemical Society Quinoline Pyrazole Antibacterial Antifungal
author_facet	Pankaj B. Miniyar Mahesh A. Barmade Anand A. Mahajan
author_sort	Pankaj B. Miniyar
title	Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents
title_short	Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents
title_full	Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents
title_fullStr	Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents
title_full_unstemmed	Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents
title_sort	synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1h-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents
publisher	Elsevier
series	Journal of Saudi Chemical Society
issn	1319-6103
publishDate	2015-11-01
description	A novel series of 2-Chloroquinoline nucleus clubbed with the pyrazole ring has been synthesized and screened for antibacterial and antifungal activity. The results obtained were promising against both bacterial and fungal strains. Among the series, compound MB-N was found moderately active against Aspergillus fumigatus, Penicillium notatum and Bacillus subtilis having MIC 48, 46 and 44 μg/ml, respectively whereas compound MB-A was found active against P. notatum, B. subtilis and Escherichia coli having MIC 57, 54 and 43 μg/ml, respectively as compared to standard.
topic	Quinoline Pyrazole Antibacterial Antifungal
url	http://www.sciencedirect.com/science/article/pii/S1319610313001348
work_keys_str_mv	AT pankajbminiyar synthesisandbiologicalevaluationof152chloroquinolin3yl3phenyl1hpyrazol1ylethanonederivativesaspotentialantimicrobialagents AT maheshabarmade synthesisandbiologicalevaluationof152chloroquinolin3yl3phenyl1hpyrazol1ylethanonederivativesaspotentialantimicrobialagents AT anandamahajan synthesisandbiologicalevaluationof152chloroquinolin3yl3phenyl1hpyrazol1ylethanonederivativesaspotentialantimicrobialagents
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Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents

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