The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications
Abstract Aminoglycosides, a class of antibiotics that includes gentamicin, kanamycin, neomycin, streptomycin, tobramycin and apramycin, are derived from various streptomyces species. Despite the significant increase in the antibacterial resistant pathogens, aminoglycosides remain an important class...
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doaj-dd17272826f74863b142c38e3caae05a2021-03-02T04:49:21ZengWiley-VCHChemistryOpen2191-13632019-09-01891154116610.1002/open.201900193The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their ApplicationsRatan W. Jadhav0Dr. Mohammad Al Kobaisi1Dr. Lathe A. Jones2Prof. Ajayan Vinu3Prof. Sheshanath V. Bhosale4School of Chemical Sciences Goa University Taleigao Plateau Goa 403 206 INDIASchool of Science, Faculty of Science, Engineering and Technology Swinburne University of Technology Hawthorn AustraliaCAMIC, School of Science RMIT University, GPO Box 2476 Melbourne, VIC-3001 AustraliaGlobal Innovative Center for Advanced Nanomaterials (GICAN) The University of Newcastle (UON), University Drive, Callaghan Callaghan NSW 2308 AustraliaSchool of Chemical Sciences Goa University Taleigao Plateau Goa 403 206 INDIAAbstract Aminoglycosides, a class of antibiotics that includes gentamicin, kanamycin, neomycin, streptomycin, tobramycin and apramycin, are derived from various streptomyces species. Despite the significant increase in the antibacterial resistant pathogens, aminoglycosides remain an important class of antimicrobial drugs due to their unique chemical structure which offers a broad spectrum of activity. The modification of antibiotics and their subsequent use in supramolecular chemistry is rarely reported. Given the importance of aminoglycosides, here we give a brief overview on the modification of 4,5‐ and 4,6‐disubstituted deoxystreptamine classes of aminoglycosides through supramolecular chemistry and their potential for real world applications. We also make the case that the work in this area is gaining momentum, and there are significant opportunities to meet the challenges of modern antibiotics through the modification of aminoglycosides by harnessing the advantages of supramolecular chemistry.https://doi.org/10.1002/open.201900193supramolecular self-assemblies, aminoglycosides, antibiotics, DNA, superstructures |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ratan W. Jadhav Dr. Mohammad Al Kobaisi Dr. Lathe A. Jones Prof. Ajayan Vinu Prof. Sheshanath V. Bhosale |
spellingShingle |
Ratan W. Jadhav Dr. Mohammad Al Kobaisi Dr. Lathe A. Jones Prof. Ajayan Vinu Prof. Sheshanath V. Bhosale The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications ChemistryOpen supramolecular self-assemblies, aminoglycosides, antibiotics, DNA, superstructures |
author_facet |
Ratan W. Jadhav Dr. Mohammad Al Kobaisi Dr. Lathe A. Jones Prof. Ajayan Vinu Prof. Sheshanath V. Bhosale |
author_sort |
Ratan W. Jadhav |
title |
The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications |
title_short |
The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications |
title_full |
The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications |
title_fullStr |
The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications |
title_full_unstemmed |
The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications |
title_sort |
supramolecular self‐assembly of aminoglycoside antibiotics and their applications |
publisher |
Wiley-VCH |
series |
ChemistryOpen |
issn |
2191-1363 |
publishDate |
2019-09-01 |
description |
Abstract Aminoglycosides, a class of antibiotics that includes gentamicin, kanamycin, neomycin, streptomycin, tobramycin and apramycin, are derived from various streptomyces species. Despite the significant increase in the antibacterial resistant pathogens, aminoglycosides remain an important class of antimicrobial drugs due to their unique chemical structure which offers a broad spectrum of activity. The modification of antibiotics and their subsequent use in supramolecular chemistry is rarely reported. Given the importance of aminoglycosides, here we give a brief overview on the modification of 4,5‐ and 4,6‐disubstituted deoxystreptamine classes of aminoglycosides through supramolecular chemistry and their potential for real world applications. We also make the case that the work in this area is gaining momentum, and there are significant opportunities to meet the challenges of modern antibiotics through the modification of aminoglycosides by harnessing the advantages of supramolecular chemistry. |
topic |
supramolecular self-assemblies, aminoglycosides, antibiotics, DNA, superstructures |
url |
https://doi.org/10.1002/open.201900193 |
work_keys_str_mv |
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