Success Rate of Radioactive Iodine Ablation in Low-Risk of Recurrence Well-Differentiated Thyroid Carcinoma Patients
Objective: To evaluate success rate and factors affecting the success of radioactive iodine (RAI) ablation in low-risk of recurrence well-differentiated thyroid carcinoma patients. Methods: Retrospective review of medical records was done in 132 low-risk of recurrence well-differentiated thyroid...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Mahidol University
2016-07-01
|
Series: | Siriraj Medical Journal |
Subjects: | |
Online Access: | http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/11/10 |
id |
doaj-dd1755fd1fb9493592afe8fdfdfffba9 |
---|---|
record_format |
Article |
spelling |
doaj-dd1755fd1fb9493592afe8fdfdfffba92020-11-24T22:41:48ZengMahidol UniversitySiriraj Medical Journal2228-80822016-07-01684229234Success Rate of Radioactive Iodine Ablation in Low-Risk of Recurrence Well-Differentiated Thyroid Carcinoma PatientsAjalaya Teyateeti0Potjanee Kanchanapiboon1Chutina Vasansirikul2Chulaluk Komoltri3Pawana Pusuwan4Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Nuclear Medicine, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Nuclear Medicine, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Research Development, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Research Development, Faculty of Medicine Siriraj Hospital, Mahidol UniversityObjective: To evaluate success rate and factors affecting the success of radioactive iodine (RAI) ablation in low-risk of recurrence well-differentiated thyroid carcinoma patients. Methods: Retrospective review of medical records was done in 132 low-risk of recurrence well-differentiated thyroid cancer (WDTC) patients between January 2007 and December 2013. All patients underwent 1) total thyroidectomy or equal surgery and 2) pre-ablative evaluationwith 99mTc-pertechnetate thyroid scan and 24-hour 131I thyroid uptake. RAI ablation using low activity (30 mCi: n = 17) or high activity (80 or 100 mCi: n = 115) were given. Success rate of each activity and a comparison of success rates between 2 doses were analyzed. Criteria of successful ablation were composed of 1) no palpable neck mass 2) no demonstrable thyroid and tumor uptake on the follow up 6-12 months diagnostic whole body scan (WBS) and 3) stimulated thyroglobulin (Tg) lower than 2 ng/mL in the absence of interfering thyroglobulin antibodies (TgAb <40 IU/mL). Factors that may affect success of radioactive iodine ablation were studied; age, gender, tumor size, stage, pathological result, number of lesions, pre-ablation 24-hour 131I thyroid uptake, serum T4, TSH, Tg and TgAb at time of ablation. Results: Overall success rate of RAI ablation was achieved in 95 patients out of 132 patients (72%). Low and high dose RAI ablation were completed in 9/17 patients (52.9%) and in 86/115 patients (74.8%), respectively (p-value = 0.082). Baseline Tg at time of ablation was a factor related to the success of ablation. Median Tg in success and failure group was 2.61 and 7.18 ng/mL, respectively (p = 0.023). Conclusion: Success of 131I ablation in low-risk of recurrence well-differentiated thyroid cancer patients was 72%. The factor relating to ablative success was Tg level at time of ablation.http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/11/10Well-differentiated thyroid cancer; low risk of recurrence; radioactive iodine ablation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ajalaya Teyateeti Potjanee Kanchanapiboon Chutina Vasansirikul Chulaluk Komoltri Pawana Pusuwan |
spellingShingle |
Ajalaya Teyateeti Potjanee Kanchanapiboon Chutina Vasansirikul Chulaluk Komoltri Pawana Pusuwan Success Rate of Radioactive Iodine Ablation in Low-Risk of Recurrence Well-Differentiated Thyroid Carcinoma Patients Siriraj Medical Journal Well-differentiated thyroid cancer; low risk of recurrence; radioactive iodine ablation |
author_facet |
Ajalaya Teyateeti Potjanee Kanchanapiboon Chutina Vasansirikul Chulaluk Komoltri Pawana Pusuwan |
author_sort |
Ajalaya Teyateeti |
title |
Success Rate of Radioactive Iodine Ablation in Low-Risk of Recurrence Well-Differentiated Thyroid Carcinoma Patients |
title_short |
Success Rate of Radioactive Iodine Ablation in Low-Risk of Recurrence Well-Differentiated Thyroid Carcinoma Patients |
title_full |
Success Rate of Radioactive Iodine Ablation in Low-Risk of Recurrence Well-Differentiated Thyroid Carcinoma Patients |
title_fullStr |
Success Rate of Radioactive Iodine Ablation in Low-Risk of Recurrence Well-Differentiated Thyroid Carcinoma Patients |
title_full_unstemmed |
Success Rate of Radioactive Iodine Ablation in Low-Risk of Recurrence Well-Differentiated Thyroid Carcinoma Patients |
title_sort |
success rate of radioactive iodine ablation in low-risk of recurrence well-differentiated thyroid carcinoma patients |
publisher |
Mahidol University |
series |
Siriraj Medical Journal |
issn |
2228-8082 |
publishDate |
2016-07-01 |
description |
Objective: To evaluate success rate and factors affecting the success of radioactive iodine (RAI) ablation in low-risk
of recurrence well-differentiated thyroid carcinoma patients.
Methods: Retrospective review of medical records was done in 132 low-risk of recurrence well-differentiated
thyroid cancer (WDTC) patients between January 2007 and December 2013. All patients underwent 1) total
thyroidectomy or equal surgery and 2) pre-ablative evaluationwith 99mTc-pertechnetate thyroid scan and 24-hour 131I thyroid uptake. RAI ablation using low activity (30 mCi: n = 17) or high activity (80 or 100 mCi: n = 115) were
given. Success rate of each activity and a comparison of success rates between 2 doses were analyzed. Criteria of
successful ablation were composed of 1) no palpable neck mass 2) no demonstrable thyroid and tumor uptake on
the follow up 6-12 months diagnostic whole body scan (WBS) and 3) stimulated thyroglobulin (Tg) lower than
2 ng/mL in the absence of interfering thyroglobulin antibodies (TgAb <40 IU/mL). Factors that may affect success
of radioactive iodine ablation were studied; age, gender, tumor size, stage, pathological result, number of lesions,
pre-ablation 24-hour 131I thyroid uptake, serum T4, TSH, Tg and TgAb at time of ablation.
Results: Overall success rate of RAI ablation was achieved in 95 patients out of 132 patients (72%). Low and
high dose RAI ablation were completed in 9/17 patients (52.9%) and in 86/115 patients (74.8%), respectively
(p-value = 0.082). Baseline Tg at time of ablation was a factor related to the success of ablation. Median Tg in
success and failure group was 2.61 and 7.18 ng/mL, respectively (p = 0.023).
Conclusion: Success of 131I ablation in low-risk of recurrence well-differentiated thyroid cancer patients was
72%. The factor relating to ablative success was Tg level at time of ablation. |
topic |
Well-differentiated thyroid cancer; low risk of recurrence; radioactive iodine ablation |
url |
http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/11/10 |
work_keys_str_mv |
AT ajalayateyateeti successrateofradioactiveiodineablationinlowriskofrecurrencewelldifferentiatedthyroidcarcinomapatients AT potjaneekanchanapiboon successrateofradioactiveiodineablationinlowriskofrecurrencewelldifferentiatedthyroidcarcinomapatients AT chutinavasansirikul successrateofradioactiveiodineablationinlowriskofrecurrencewelldifferentiatedthyroidcarcinomapatients AT chulalukkomoltri successrateofradioactiveiodineablationinlowriskofrecurrencewelldifferentiatedthyroidcarcinomapatients AT pawanapusuwan successrateofradioactiveiodineablationinlowriskofrecurrencewelldifferentiatedthyroidcarcinomapatients |
_version_ |
1725700712717877248 |