POOR HEMOPOIETIC STEM CELL MOBILIZERS IN MULTIPLE MYELOMA : A SINGLE INSTITUTION EXPERIENCE
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 200%; text-align: justify; tab-stops: 248.1pt;"><strong style="mso-bidi-font-weight: normal;"><span style="font-family: Arial; mso-ansi-language: EN-US;" lang=&quo...
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doaj-dd2551d8f9144a59b9d1e37cb2610dcd2020-11-24T23:07:28ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062010-05-0122e2010016e2010016POOR HEMOPOIETIC STEM CELL MOBILIZERS IN MULTIPLE MYELOMA : A SINGLE INSTITUTION EXPERIENCEAura Ramirez-MedinaAna Hernandez-ArizpeAvril Lopez-OteroGuillermo Jose Ruiz-DelgadoGuillermo Jose Ruiz-Argüelles<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 200%; text-align: justify; tab-stops: 248.1pt;"><strong style="mso-bidi-font-weight: normal;"><span style="font-family: Arial; mso-ansi-language: EN-US;" lang="EN-US"><span style="font-size: small;"><span style="mso-spacerun: yes;"> </span>In a single institution, in a group of 28<span style="mso-bidi-font-weight: bold;"> myeloma patients deemed eligible for autologous transplant, stem cell mobilization was attempted using filgrastim: 26 individuals were given 31 autografts employing 1-4 (median three) apheresis sessions, to obtain a target stem cell dose of 1 x 10<sup>6</sup> CD34 viable cells / Kg of the recipient. The median number of grafted CD34 cells was 7.56 x 10<sup>6</sup><span style="mso-spacerun: yes;"> </span>/ Kg of the recipient; the range being 0.92 to 14.8.<span style="mso-spacerun: yes;"> </span>By defining as poor mobilizers individuals in which a cell collection of < 1 x 10<sup>6</sup> CD34 viable cells / Kg was obtained, a subset of eight poor mobilizers was identified; in two patients the autograft was aborted because of an extremely poor CD34 cell yield (< 0.2 x 10<sup>6</sup> CD34 viable cells / Kg of the recipient) after four apheresis sessions. The long-term overall survival of the patients grafted with > 1 x 10<sup>6</sup> CD34 viable cells / Kg was better (80% at 80 months) than those grafted with < 1 x 10<sup>6</sup> CD34 viable cells / Kg (67% at 76 months). Methods to improve stem cell mobilization are needed and may result in obtaining better results when autografting multiple myeloma patients.</span></span></span></strong></p>http://www.mjhid.org/article/view/6020myeloma, mobilization, autotransplant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aura Ramirez-Medina Ana Hernandez-Arizpe Avril Lopez-Otero Guillermo Jose Ruiz-Delgado Guillermo Jose Ruiz-Argüelles |
spellingShingle |
Aura Ramirez-Medina Ana Hernandez-Arizpe Avril Lopez-Otero Guillermo Jose Ruiz-Delgado Guillermo Jose Ruiz-Argüelles POOR HEMOPOIETIC STEM CELL MOBILIZERS IN MULTIPLE MYELOMA : A SINGLE INSTITUTION EXPERIENCE Mediterranean Journal of Hematology and Infectious Diseases myeloma, mobilization, autotransplant |
author_facet |
Aura Ramirez-Medina Ana Hernandez-Arizpe Avril Lopez-Otero Guillermo Jose Ruiz-Delgado Guillermo Jose Ruiz-Argüelles |
author_sort |
Aura Ramirez-Medina |
title |
POOR HEMOPOIETIC STEM CELL MOBILIZERS IN MULTIPLE MYELOMA : A SINGLE INSTITUTION EXPERIENCE |
title_short |
POOR HEMOPOIETIC STEM CELL MOBILIZERS IN MULTIPLE MYELOMA : A SINGLE INSTITUTION EXPERIENCE |
title_full |
POOR HEMOPOIETIC STEM CELL MOBILIZERS IN MULTIPLE MYELOMA : A SINGLE INSTITUTION EXPERIENCE |
title_fullStr |
POOR HEMOPOIETIC STEM CELL MOBILIZERS IN MULTIPLE MYELOMA : A SINGLE INSTITUTION EXPERIENCE |
title_full_unstemmed |
POOR HEMOPOIETIC STEM CELL MOBILIZERS IN MULTIPLE MYELOMA : A SINGLE INSTITUTION EXPERIENCE |
title_sort |
poor hemopoietic stem cell mobilizers in multiple myeloma : a single institution experience |
publisher |
PAGEPress Publications |
series |
Mediterranean Journal of Hematology and Infectious Diseases |
issn |
2035-3006 |
publishDate |
2010-05-01 |
description |
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 200%; text-align: justify; tab-stops: 248.1pt;"><strong style="mso-bidi-font-weight: normal;"><span style="font-family: Arial; mso-ansi-language: EN-US;" lang="EN-US"><span style="font-size: small;"><span style="mso-spacerun: yes;"> </span>In a single institution, in a group of 28<span style="mso-bidi-font-weight: bold;"> myeloma patients deemed eligible for autologous transplant, stem cell mobilization was attempted using filgrastim: 26 individuals were given 31 autografts employing 1-4 (median three) apheresis sessions, to obtain a target stem cell dose of 1 x 10<sup>6</sup> CD34 viable cells / Kg of the recipient. The median number of grafted CD34 cells was 7.56 x 10<sup>6</sup><span style="mso-spacerun: yes;"> </span>/ Kg of the recipient; the range being 0.92 to 14.8.<span style="mso-spacerun: yes;"> </span>By defining as poor mobilizers individuals in which a cell collection of < 1 x 10<sup>6</sup> CD34 viable cells / Kg was obtained, a subset of eight poor mobilizers was identified; in two patients the autograft was aborted because of an extremely poor CD34 cell yield (< 0.2 x 10<sup>6</sup> CD34 viable cells / Kg of the recipient) after four apheresis sessions. The long-term overall survival of the patients grafted with > 1 x 10<sup>6</sup> CD34 viable cells / Kg was better (80% at 80 months) than those grafted with < 1 x 10<sup>6</sup> CD34 viable cells / Kg (67% at 76 months). Methods to improve stem cell mobilization are needed and may result in obtaining better results when autografting multiple myeloma patients.</span></span></span></strong></p> |
topic |
myeloma, mobilization, autotransplant |
url |
http://www.mjhid.org/article/view/6020 |
work_keys_str_mv |
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