Structural basis of ligand interaction with atypical chemokine receptor 3
The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ligand-induced conformational changes in ACKR3.
Bibliographic Details
Main Authors: |
Martin Gustavsson,
Liwen Wang,
Noortje van Gils,
Bryan S. Stephens,
Penglie Zhang,
Thomas J. Schall,
Sichun Yang,
Ruben Abagyan,
Mark R. Chance,
Irina Kufareva,
Tracy M. Handel |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-01-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms14135
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