In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders

In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders

Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterised by restrictive patterns of behaviour and alterations in social interaction and communication. Up to 80% of children with ASD exhibit sleep-wake cycle disturbances, emphasising the pressing need for novel approach...

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Bibliographic Details
Main Authors: Sarah Ferraro, Nuria de Zavalia, Nicolas Belforte, Shimon Amir
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
autism spectrum disorder
circadian rhythms
valproic acid
clock-gene
rodent model
rhythm disturbances
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.711549/full

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