Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice.
In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons ap...
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2009-09-01
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doaj-dd2e2e3f120d4586bfabbe1afbfc851f2020-11-24T21:34:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-09-0149e701710.1371/journal.pone.0007017Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice.Françoise LazariniMarc-André MouthonGilles GheusiFabrice de ChaumontJean-Christophe Olivo-MarinStéphanie LamarqueDjoher Nora AbrousFrançois D BoussinPierre-Marie LledoIn mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear.In this study, we irradiated adult mice to impair constitutive OB neurogenesis, and explored the functional impacts of this irradiation on the sense of smell. We found that focal irradiation of the SVZ greatly decreased the rate of production of new OB neurons, leaving other brain areas intact. This effect persisted for up to seven months after exposure to 15 Gray. Despite this robust impairment, the thresholds for detecting pure odorant molecules and short-term olfactory memory were not affected by irradiation. Similarly, the ability to distinguish between odorant molecules and the odorant-guided social behavior of irradiated mice were not affected by the decrease in the number of new neurons. Only long-term olfactory memory was found to be sensitive to SVZ irradiation.These findings suggest that the continuous production of adult-generated neurons is involved in consolidating or restituting long-lasting olfactory traces.http://europepmc.org/articles/PMC2737283?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Françoise Lazarini Marc-André Mouthon Gilles Gheusi Fabrice de Chaumont Jean-Christophe Olivo-Marin Stéphanie Lamarque Djoher Nora Abrous François D Boussin Pierre-Marie Lledo |
spellingShingle |
Françoise Lazarini Marc-André Mouthon Gilles Gheusi Fabrice de Chaumont Jean-Christophe Olivo-Marin Stéphanie Lamarque Djoher Nora Abrous François D Boussin Pierre-Marie Lledo Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. PLoS ONE |
author_facet |
Françoise Lazarini Marc-André Mouthon Gilles Gheusi Fabrice de Chaumont Jean-Christophe Olivo-Marin Stéphanie Lamarque Djoher Nora Abrous François D Boussin Pierre-Marie Lledo |
author_sort |
Françoise Lazarini |
title |
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. |
title_short |
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. |
title_full |
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. |
title_fullStr |
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. |
title_full_unstemmed |
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. |
title_sort |
cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2009-09-01 |
description |
In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear.In this study, we irradiated adult mice to impair constitutive OB neurogenesis, and explored the functional impacts of this irradiation on the sense of smell. We found that focal irradiation of the SVZ greatly decreased the rate of production of new OB neurons, leaving other brain areas intact. This effect persisted for up to seven months after exposure to 15 Gray. Despite this robust impairment, the thresholds for detecting pure odorant molecules and short-term olfactory memory were not affected by irradiation. Similarly, the ability to distinguish between odorant molecules and the odorant-guided social behavior of irradiated mice were not affected by the decrease in the number of new neurons. Only long-term olfactory memory was found to be sensitive to SVZ irradiation.These findings suggest that the continuous production of adult-generated neurons is involved in consolidating or restituting long-lasting olfactory traces. |
url |
http://europepmc.org/articles/PMC2737283?pdf=render |
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