The possible Association of HLA Class II with Bladder Cancer in Iraqi Patients

• Main Authors: Shatha M.J. Al-Khateeb, Aida- Al-Darzy, Khalida M. Al-Mousawy, Nasr F. Al-Rubaee, Shwaqi J. Ghazala
• Format: Article
• Language: English
• Published: Faculty of Medicine University of Baghdad 2008-01-01
• Series: مجلة كلية الطب
• Subjects: Bladder Cancer BC, Human Leukocyte Antigen HLA.
• Online Access: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1335
• ISSN: 0041-9419; 2410-8057

Background: - Genetic Factors have a major role in the development of bladder cancer. Objectives: - This study was carried out to shed a light on the possible association of HLA class II antigens and BC patients and to correlate this finding with the family history. Patients and Methodes :- Lymphocytotxicity assay had been used to assess HLAtyping of 65 BC patients and 50 healthy controls. Results:- comparison between BC patients and healthy controls showed several antigens deviations in their frequencies. HLA-DR1, HLA-DQ1 and HLA-DQ3 antigens were observed with increased frequencies in patients group with significant differences (P=0.000, 0.000 and 0.017 respectively). Moreover there was decrease frequency of HLA-DR7 in patients group (P=0.010). Stastical analysis showed non significant correlation of the specific HLA –Ags with family history. Conclusions: - This finding demonstrated that HLA-DR1, DR7, DQ1 and DQ3 might play a role in BC susceptibility. • Department of clinical biochemistry. Collage of Medicine Al-Mustansyriah University • Department of Microbiology. Collage of Medicine. Baghdad University • Ministry of Health.