CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series
AIM: To report CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease (IgG4-MALT lymphoma), a rare but clinically important complication of ocular adnexal IgG4-related disease. METHODS: We retrospectively reviewed all cases of hi...
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Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2020-08-01
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Series: | International Journal of Ophthalmology |
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Online Access: | http://ies.ijo.cn/en_publish/2020/8/20200808.pdf |
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doaj-dd3d4301d5af4805aa5e7f1683ec0889 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roh-Eul Yoo Sun-Won Park Jung Hyo Rhim Ji Eun Kim Soo Chin Kim Ji-Young Choe Ho-Kyung Choung Sang In Khwarg Ji-hoon Kim Jeong Hyun Lee Bo Eun Lee Yeonah Kang |
spellingShingle |
Roh-Eul Yoo Sun-Won Park Jung Hyo Rhim Ji Eun Kim Soo Chin Kim Ji-Young Choe Ho-Kyung Choung Sang In Khwarg Ji-hoon Kim Jeong Hyun Lee Bo Eun Lee Yeonah Kang CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series International Journal of Ophthalmology ct igg4-related disease mr ocular adnexal mucosa-associated lymphoid tissue lymphoma |
author_facet |
Roh-Eul Yoo Sun-Won Park Jung Hyo Rhim Ji Eun Kim Soo Chin Kim Ji-Young Choe Ho-Kyung Choung Sang In Khwarg Ji-hoon Kim Jeong Hyun Lee Bo Eun Lee Yeonah Kang |
author_sort |
Roh-Eul Yoo |
title |
CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series |
title_short |
CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series |
title_full |
CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series |
title_fullStr |
CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series |
title_full_unstemmed |
CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series |
title_sort |
ct and mr imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with igg4-related disease: multi-institutional case series |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2020-08-01 |
description |
AIM: To report CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease (IgG4-MALT lymphoma), a rare but clinically important complication of ocular adnexal IgG4-related disease.
METHODS: We retrospectively reviewed all cases of histologically confirmed ocular adnexal IgG4-related disease at three tertiary and one secondary referral centers, between February 2003 and December 2016. Seven cases of histopathologically diagnosed IgG4-MALT lymphoma were identified. CT and MR images were analyzed by consensus of two experienced head and neck radiologists.
RESULTS: Lacrimal glands were the main site of involvement in all seven patients. The lesions typically showed well-demarcated margins, iso- to hyperattenuation on precontrast CT, T2 hypo- to isointensity, T1 isointensity, and homogenous internal architecture with homogenous enhancement pattern. Lesions were mostly hyperdense and isointense to normal extraocular muscles on postcontrast CT and MR images, respectively.
CONCLUSION: Unlike in typical ocular adnexal IgG4-related disease, T2 isointensity and hyperattenuation on precontrast CT images were noted in some IgG4-MALT lymphoma cases. Although the findings may be nonspecific, the possibility of accompanying MALT lymphoma may need to be considered, when ocular adnexal lesions in patients clinically suspected of having IgG4-related disease are refractory to glucocorticoids and show T2 isointensity and hyperattenuation on precontrast CT for the optimal management of the patients. However, this is a case series of a very rare complication of ocular adnexal IgG4-related disease, and thus caution is warranted to generalize the conclusion. |
topic |
ct igg4-related disease mr ocular adnexal mucosa-associated lymphoid tissue lymphoma |
url |
http://ies.ijo.cn/en_publish/2020/8/20200808.pdf |
work_keys_str_mv |
AT roheulyoo ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT sunwonpark ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT junghyorhim ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT jieunkim ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT soochinkim ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT jiyoungchoe ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT hokyungchoung ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT sanginkhwarg ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT jihoonkim ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT jeonghyunlee ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT boeunlee ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries AT yeonahkang ctandmrimagingfindingsofocularadnexalmucosaassociatedlymphoidtissuelymphomaassociatedwithigg4relateddiseasemultiinstitutionalcaseseries |
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doaj-dd3d4301d5af4805aa5e7f1683ec08892020-11-25T03:33:04ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982020-08-011381231123710.18240/ijo.2020.08.08CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case seriesRoh-Eul Yoo0Sun-Won Park1Jung Hyo Rhim2Ji Eun Kim3Soo Chin Kim4Ji-Young Choe5Ho-Kyung Choung6Sang In Khwarg7Ji-hoon Kim8Jeong Hyun Lee9Bo Eun Lee10Yeonah Kang11Department of Radiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiology, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Radiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 07061, Republic of KoreaDepartment of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 07061, Republic of KoreaDepartment of Pathology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea; Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of KoreaDepartment of Radiology, Asan Medical Center, Seoul 05505, Republic of KoreaDepartment of Pathology, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDepartment of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea; Department of Ophthalmology, Seoul National University College of Medicine, Seoul 03080, Republic of KoreaDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul 03080, Republic of KoreaDepartment of Radiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiology, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Radiology, Asan Medical Center, Seoul 05505, Republic of Korea; Department of Radiology, Ulsan University College of Medicine, Seoul 05505, Republic of KoreaDepartment of Radiology, Asan Medical Center, Seoul 05505, Republic of Korea; Department of Radiology, Ulsan University College of Medicine, Seoul 05505, Republic of KoreaDepartment of Radiology, Inje University Haeundae Paik Hospital, Busan 47392, Republic of KoreaAIM: To report CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease (IgG4-MALT lymphoma), a rare but clinically important complication of ocular adnexal IgG4-related disease. METHODS: We retrospectively reviewed all cases of histologically confirmed ocular adnexal IgG4-related disease at three tertiary and one secondary referral centers, between February 2003 and December 2016. Seven cases of histopathologically diagnosed IgG4-MALT lymphoma were identified. CT and MR images were analyzed by consensus of two experienced head and neck radiologists. RESULTS: Lacrimal glands were the main site of involvement in all seven patients. The lesions typically showed well-demarcated margins, iso- to hyperattenuation on precontrast CT, T2 hypo- to isointensity, T1 isointensity, and homogenous internal architecture with homogenous enhancement pattern. Lesions were mostly hyperdense and isointense to normal extraocular muscles on postcontrast CT and MR images, respectively. CONCLUSION: Unlike in typical ocular adnexal IgG4-related disease, T2 isointensity and hyperattenuation on precontrast CT images were noted in some IgG4-MALT lymphoma cases. Although the findings may be nonspecific, the possibility of accompanying MALT lymphoma may need to be considered, when ocular adnexal lesions in patients clinically suspected of having IgG4-related disease are refractory to glucocorticoids and show T2 isointensity and hyperattenuation on precontrast CT for the optimal management of the patients. However, this is a case series of a very rare complication of ocular adnexal IgG4-related disease, and thus caution is warranted to generalize the conclusion.http://ies.ijo.cn/en_publish/2020/8/20200808.pdfctigg4-related diseasemrocular adnexal mucosa-associated lymphoid tissue lymphoma |