Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival
Abstract Background The precise classification of idiopathic interstitial pneumonia (IIP) is essential for selecting treatment as well as estimating clinical outcomes; however, this is sometimes difficult in clinical practice. Therefore, cluster analysis was used to identify the clinical phenotypes...
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doaj-dd488beddbca4aaf9b3ee6dda2b688d82021-02-23T09:14:47ZengBMCBMC Pulmonary Medicine1471-24662021-02-012111910.1186/s12890-021-01428-3Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survivalYoichiro Aoshima0Masato Karayama1Yasuoki Horiike2Kazutaka Mori3Hideki Yasui4Hironao Hozumi5Yuzo Suzuki6Kazuki Furuhashi7Tomoyuki Fujisawa8Noriyuki Enomoto9Yutaro Nakamura10Naoki Inui11Takafumi Suda12Second Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineDepartment of Respiratory Medicine, Shizuoka City Shimizu HospitalSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineAbstract Background The precise classification of idiopathic interstitial pneumonia (IIP) is essential for selecting treatment as well as estimating clinical outcomes; however, this is sometimes difficult in clinical practice. Therefore, cluster analysis was used to identify the clinical phenotypes of IIPs, and its usefulness for predicting clinical outcomes was evaluated. Methods Cluster analysis was performed using clinical features including patients’ demographics; histories; pulmonary function test data; and laboratory, physical and radiological findings. Results In 337 patients with IIPs, four clusters were identified: Cluster I, in which > 80% of the patients had autoimmune features; Cluster II, which had the lowest rate of smoking, the lowest percent predicted forced vital capacity (%FVC) and the lowest body mass index (BMI); Cluster III, which had the highest rate of smoking, the highest rate of dust exposure, the second lowest %FVC and normal BMI; and Cluster IV, which exhibited maintenance of %FVC and normal BMI. Cluster IV had significantly longer overall survival than Clusters II and III. Clusters I and III had significantly longer overall survival than Cluster II. Clusters II and III had a significantly higher cumulative incidence of acute exacerbation than Cluster IV. Conclusion Cluster analysis using clinical features identified four clinical phenotypes of IIPs, which may be useful for predicting the risk of acute exacerbation and overall survival.https://doi.org/10.1186/s12890-021-01428-3Idiopathic pulmonary fibrosisInterstitial lung diseaseInterstitial pneumoniaIPAFIPF |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoichiro Aoshima Masato Karayama Yasuoki Horiike Kazutaka Mori Hideki Yasui Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Noriyuki Enomoto Yutaro Nakamura Naoki Inui Takafumi Suda |
spellingShingle |
Yoichiro Aoshima Masato Karayama Yasuoki Horiike Kazutaka Mori Hideki Yasui Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Noriyuki Enomoto Yutaro Nakamura Naoki Inui Takafumi Suda Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival BMC Pulmonary Medicine Idiopathic pulmonary fibrosis Interstitial lung disease Interstitial pneumonia IPAF IPF |
author_facet |
Yoichiro Aoshima Masato Karayama Yasuoki Horiike Kazutaka Mori Hideki Yasui Hironao Hozumi Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Noriyuki Enomoto Yutaro Nakamura Naoki Inui Takafumi Suda |
author_sort |
Yoichiro Aoshima |
title |
Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival |
title_short |
Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival |
title_full |
Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival |
title_fullStr |
Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival |
title_full_unstemmed |
Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival |
title_sort |
cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival |
publisher |
BMC |
series |
BMC Pulmonary Medicine |
issn |
1471-2466 |
publishDate |
2021-02-01 |
description |
Abstract Background The precise classification of idiopathic interstitial pneumonia (IIP) is essential for selecting treatment as well as estimating clinical outcomes; however, this is sometimes difficult in clinical practice. Therefore, cluster analysis was used to identify the clinical phenotypes of IIPs, and its usefulness for predicting clinical outcomes was evaluated. Methods Cluster analysis was performed using clinical features including patients’ demographics; histories; pulmonary function test data; and laboratory, physical and radiological findings. Results In 337 patients with IIPs, four clusters were identified: Cluster I, in which > 80% of the patients had autoimmune features; Cluster II, which had the lowest rate of smoking, the lowest percent predicted forced vital capacity (%FVC) and the lowest body mass index (BMI); Cluster III, which had the highest rate of smoking, the highest rate of dust exposure, the second lowest %FVC and normal BMI; and Cluster IV, which exhibited maintenance of %FVC and normal BMI. Cluster IV had significantly longer overall survival than Clusters II and III. Clusters I and III had significantly longer overall survival than Cluster II. Clusters II and III had a significantly higher cumulative incidence of acute exacerbation than Cluster IV. Conclusion Cluster analysis using clinical features identified four clinical phenotypes of IIPs, which may be useful for predicting the risk of acute exacerbation and overall survival. |
topic |
Idiopathic pulmonary fibrosis Interstitial lung disease Interstitial pneumonia IPAF IPF |
url |
https://doi.org/10.1186/s12890-021-01428-3 |
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