Correlation of peripheral blood COS, OX40 and CD40 expression with disease activity in patients with lupus nephritis

• Main Authors: Wei Peng, Li-Ping Shen
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-08-01
• Series: Journal of Hainan Medical University
• Subjects: Lupus nephritis; ICOS; OX40; CD40; Helper T cell
• Online Access: http://www.hnykdxxb.com/PDF/201715/12.pdf

Objective: To study the correlation of peripheral blood COS, OX40 and CD40 expression with disease activity in patients with lupus nephritis (LN). Methods: Patients who were diagnosed with stable and active lupus nephritis in Zigong First People's Hospital between May 2014 and March 2017 were selected and enrolled in stable LN group and active LN group respectively; healthy volunteers who received physical examination during the same period were chosen as control group. The ICOS, OX40 and CD40 mRNA expression in peripheral blood nuclear cells as well as the levels of cytokines and disease activity-related indexes in serum were measured. Results: ICOS, OX40 and CD40 mRNA expression in peripheral blood mononuclear cells as well as IL-4, IL-5, IL-10, anti-C1q antibody and anti-ds-DNA antibody levels in serum of stable LN group and active LN group were significantly higher than those of control group while TNF-α, IFN-γ, C3 and C4 levels in serum were significantly lower than those of control group; the changes in active LN group were more significant than those in stable LN group; ICOS, OX40 and CD40 mRNA expression in peripheral blood mononuclear cells of patients with LN were positively correlated with IL-4, IL-5, IL-10, anti-C1q antibody and antids- DNA antibody levels in serum, and negatively correlated with TNF-α, IFN-γ, C3 and C4 levels in serum. Conclusion: High expression of ICOS, OX40 and CD40 in the peripheral blood of patients with LN are closely related to the Th1/Th2 shifting and the disease activity.