Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria

Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria

Perilipin 2 (PLIN2) is a lipid droplet (LD) protein in β cells that increases under nutritional stress. Downregulation of PLIN2 is often sufficient to reduce LD accumulation. To determine whether PLIN2 positively or negatively affects β cell function under nutritional stress, PLIN2 was downregulated...

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Bibliographic Details
Main Authors: Akansha Mishra, Siming Liu, Joseph Promes, Mikako Harata, William Sivitz, Brian Fink, Gourav Bhardwaj, Brian T. O’Neill, Chen Kang, Rajan Sah, Stefan Strack, Samuel Stephens, Timothy King, Laura Jackson, Andrew S. Greenberg, Frederick Anokye-Danso, Rexford S. Ahima, James Ankrum, Yumi Imai
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-05-01
Series:JCI Insight
Subjects:
Endocrinology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.144341

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