The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms

The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms

Tenacibaculum maritimum is a devastating bacterial pathogen of wild and farmed marine fish with a broad host range and a worldwide distribution. We report here the complete genome sequence of the T. maritimum type strain NCIMB 2154T. The genome consists of a 3,435,971-base pair circular chromosome w...

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Main Authors: David Pérez-Pascual, Aurelie Lunazzi, Ghislaine Magdelenat, Zoe Rouy, Alain Roulet, Celine Lopez-Roques, Robert Larocque, Tristan Barbeyron, Angélique Gobet, Gurvan Michel, Jean-François Bernardet, Eric Duchaud
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Microbiology
Subjects:
Tenacibaculum maritimum
fish pathogen
virulence factors
genome
toxins
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01542/full
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spelling doaj-dd5479c30b684772a5ce61bcc2c912872020-11-24T23:01:20ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-08-01810.3389/fmicb.2017.01542263568The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence MechanismsDavid Pérez-Pascual0Aurelie Lunazzi1Ghislaine Magdelenat2Zoe Rouy3Alain Roulet4Alain Roulet5Celine Lopez-Roques6Celine Lopez-Roques7Robert Larocque8Tristan Barbeyron9Angélique Gobet10Gurvan Michel11Jean-François Bernardet12Eric Duchaud13Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-SaclayJouy-en-Josas, FranceVirologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-SaclayJouy-en-Josas, FranceCommissariat à l’Énergie Atomique et aux Énergies Alternatives, Institut de Génomique, GenoscopeEvry, FranceLaboratoire d’Analyses Bioinformatiques en Génomique et Métabolisme, Centre National de la Recherche Scientifique (UMR-8030), Commissariat à l’Énergie Atomique et aux Énergies Alternatives, Institut de Génomique, GenoscopeEvry, FranceGenotoul Genome & Transcriptome (GeT-PlaGe), Institut National de la Recherche AgronomiqueCastanet-Tolosan, FranceInstitut National de la Recherche Agronomique (UAR1209)Castanet-Tolosan, FranceGenotoul Genome & Transcriptome (GeT-PlaGe), Institut National de la Recherche AgronomiqueCastanet-Tolosan, FranceInstitut National de la Recherche Agronomique (UAR1209)Castanet-Tolosan, FranceLaboratoire de Biologie Intégrative des Modèles Marins (UMR 8227), Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, Station Biologique de Roscoff, Sorbonne UniversitésRoscoff, FranceLaboratoire de Biologie Intégrative des Modèles Marins (UMR 8227), Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, Station Biologique de Roscoff, Sorbonne UniversitésRoscoff, FranceLaboratoire de Biologie Intégrative des Modèles Marins (UMR 8227), Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, Station Biologique de Roscoff, Sorbonne UniversitésRoscoff, FranceLaboratoire de Biologie Intégrative des Modèles Marins (UMR 8227), Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, Station Biologique de Roscoff, Sorbonne UniversitésRoscoff, FranceVirologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-SaclayJouy-en-Josas, FranceVirologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-SaclayJouy-en-Josas, FranceTenacibaculum maritimum is a devastating bacterial pathogen of wild and farmed marine fish with a broad host range and a worldwide distribution. We report here the complete genome sequence of the T. maritimum type strain NCIMB 2154T. The genome consists of a 3,435,971-base pair circular chromosome with 2,866 predicted protein-coding genes. Genes encoding the biosynthesis of exopolysaccharides, the type IX secretion system, iron uptake systems, adhesins, hemolysins, proteases, and glycoside hydrolases were identified. They are likely involved in the virulence process including immune escape, invasion, colonization, destruction of host tissues, and nutrient scavenging. Among the predicted virulence factors, type IX secretion-mediated and cell-surface exposed proteins were identified including an atypical sialidase, a sphingomyelinase and a chondroitin AC lyase which activities were demonstrated in vitro.http://journal.frontiersin.org/article/10.3389/fmicb.2017.01542/fullTenacibaculum maritimumfish pathogenvirulence factorsgenometoxins
collection DOAJ
language English
format Article
sources DOAJ
author David Pérez-Pascual
Aurelie Lunazzi
Ghislaine Magdelenat
Zoe Rouy
Alain Roulet
Alain Roulet
Celine Lopez-Roques
Celine Lopez-Roques
Robert Larocque
Tristan Barbeyron
Angélique Gobet
Gurvan Michel
Jean-François Bernardet
Eric Duchaud
spellingShingle David Pérez-Pascual
Aurelie Lunazzi
Ghislaine Magdelenat
Zoe Rouy
Alain Roulet
Alain Roulet
Celine Lopez-Roques
Celine Lopez-Roques
Robert Larocque
Tristan Barbeyron
Angélique Gobet
Gurvan Michel
Jean-François Bernardet
Eric Duchaud
The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms
Frontiers in Microbiology
Tenacibaculum maritimum
fish pathogen
virulence factors
genome
toxins
author_facet David Pérez-Pascual
Aurelie Lunazzi
Ghislaine Magdelenat
Zoe Rouy
Alain Roulet
Alain Roulet
Celine Lopez-Roques
Celine Lopez-Roques
Robert Larocque
Tristan Barbeyron
Angélique Gobet
Gurvan Michel
Jean-François Bernardet
Eric Duchaud
author_sort David Pérez-Pascual
title The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms
title_short The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms
title_full The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms
title_fullStr The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms
title_full_unstemmed The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms
title_sort complete genome sequence of the fish pathogen tenacibaculum maritimum provides insights into virulence mechanisms
publisher Frontiers Media S.A.
series Frontiers in Microbiology
issn 1664-302X
publishDate 2017-08-01
description Tenacibaculum maritimum is a devastating bacterial pathogen of wild and farmed marine fish with a broad host range and a worldwide distribution. We report here the complete genome sequence of the T. maritimum type strain NCIMB 2154T. The genome consists of a 3,435,971-base pair circular chromosome with 2,866 predicted protein-coding genes. Genes encoding the biosynthesis of exopolysaccharides, the type IX secretion system, iron uptake systems, adhesins, hemolysins, proteases, and glycoside hydrolases were identified. They are likely involved in the virulence process including immune escape, invasion, colonization, destruction of host tissues, and nutrient scavenging. Among the predicted virulence factors, type IX secretion-mediated and cell-surface exposed proteins were identified including an atypical sialidase, a sphingomyelinase and a chondroitin AC lyase which activities were demonstrated in vitro.
topic Tenacibaculum maritimum
fish pathogen
virulence factors
genome
toxins
url http://journal.frontiersin.org/article/10.3389/fmicb.2017.01542/full
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