Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels

Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels

Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive me...

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Main Authors: Trivia Frazier, Andrea Alarcon, Xiying Wu, Omair A. Mohiuddin, Jessica M. Motherwell, Anders H. Carlsson, Robert J. Christy, Judson V. Edwards, Robert T. Mackin, Nicolette Prevost, Elena Gloster, Qiang Zhang, Guangdi Wang, Daniel J. Hayes, Jeffrey M. Gimble
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
adipose-derived stromal/stem cells (ASC)
blood
burns
cellulose
exosome
platelets
Online Access:https://www.mdpi.com/2218-273X/10/10/1373
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spelling doaj-dd5544bfed604980a30220c80c22b8e82020-11-25T03:00:06ZengMDPI AGBiomolecules2218-273X2020-09-01101373137310.3390/biom10101373Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and HydrogelsTrivia Frazier0Andrea Alarcon1Xiying Wu2Omair A. Mohiuddin3Jessica M. Motherwell4Anders H. Carlsson5Robert J. Christy6Judson V. Edwards7Robert T. Mackin8Nicolette Prevost9Elena Gloster10Qiang Zhang11Guangdi Wang12Daniel J. Hayes13Jeffrey M. Gimble14Obatala Sciences Inc., New Orleans, LA 70148, USAObatala Sciences Inc., New Orleans, LA 70148, USAObatala Sciences Inc., New Orleans, LA 70148, USAPanjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Science, University of Karachi, Karachi 75270, PakistanWalter Reed National Military Medical Center, Bethesda, MD 29814, USAUnited States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX 78234, USAUnited States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX 78234, USASouthern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USASouthern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USASouthern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USADepartment of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USADepartment of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USADepartment of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USADepartment of Biomedical Engineering, State College, Pennsylvania State University, PA 16802, USAObatala Sciences Inc., New Orleans, LA 70148, USAAcute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose-, blood-, and cellulose-derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.https://www.mdpi.com/2218-273X/10/10/1373adipose-derived stromal/stem cells (ASC)bloodburnscelluloseexosomeplatelets
collection DOAJ
language English
format Article
sources DOAJ
author Trivia Frazier
Andrea Alarcon
Xiying Wu
Omair A. Mohiuddin
Jessica M. Motherwell
Anders H. Carlsson
Robert J. Christy
Judson V. Edwards
Robert T. Mackin
Nicolette Prevost
Elena Gloster
Qiang Zhang
Guangdi Wang
Daniel J. Hayes
Jeffrey M. Gimble
spellingShingle Trivia Frazier
Andrea Alarcon
Xiying Wu
Omair A. Mohiuddin
Jessica M. Motherwell
Anders H. Carlsson
Robert J. Christy
Judson V. Edwards
Robert T. Mackin
Nicolette Prevost
Elena Gloster
Qiang Zhang
Guangdi Wang
Daniel J. Hayes
Jeffrey M. Gimble
Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels
Biomolecules
adipose-derived stromal/stem cells (ASC)
blood
burns
cellulose
exosome
platelets
author_facet Trivia Frazier
Andrea Alarcon
Xiying Wu
Omair A. Mohiuddin
Jessica M. Motherwell
Anders H. Carlsson
Robert J. Christy
Judson V. Edwards
Robert T. Mackin
Nicolette Prevost
Elena Gloster
Qiang Zhang
Guangdi Wang
Daniel J. Hayes
Jeffrey M. Gimble
author_sort Trivia Frazier
title Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels
title_short Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels
title_full Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels
title_fullStr Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels
title_full_unstemmed Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels
title_sort clinical translational potential in skin wound regeneration for adipose-derived, blood-derived, and cellulose materials: cells, exosomes, and hydrogels
publisher MDPI AG
series Biomolecules
issn 2218-273X
publishDate 2020-09-01
description Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose-, blood-, and cellulose-derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.
topic adipose-derived stromal/stem cells (ASC)
blood
burns
cellulose
exosome
platelets
url https://www.mdpi.com/2218-273X/10/10/1373
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