Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
Circulating lipoprotein(a) is an important risk factor for cardiovascular disease and shows variability between different ethnic groups. Here, Zekavat et al. perform whole-genome sequencing in individuals of European and African ancestries and find ancestry-specific genetic determinants for lipoprot...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04668-w |
| id |
doaj-dd61e81e8545472a93ddce68c769d81d |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Seyedeh M. Zekavat Sanni Ruotsalainen Robert E. Handsaker Maris Alver Jonathan Bloom Timothy Poterba Cotton Seed Jason Ernst Mark Chaffin Jesse Engreitz Gina M. Peloso Ani Manichaikul Chaojie Yang Kathleen A. Ryan Mao Fu W. Craig Johnson Michael Tsai Matthew Budoff Ramachandran S. Vasan L. Adrienne Cupples Jerome I. Rotter Stephen S. Rich Wendy Post Braxton D. Mitchell Adolfo Correa Andres Metspalu James G. Wilson Veikko Salomaa Manolis Kellis Mark J. Daly Benjamin M. Neale Steven McCarroll Ida Surakka Tonu Esko Andrea Ganna Samuli Ripatti Sekar Kathiresan Pradeep Natarajan NHLBI TOPMed Lipids Working Group |
| spellingShingle |
Seyedeh M. Zekavat Sanni Ruotsalainen Robert E. Handsaker Maris Alver Jonathan Bloom Timothy Poterba Cotton Seed Jason Ernst Mark Chaffin Jesse Engreitz Gina M. Peloso Ani Manichaikul Chaojie Yang Kathleen A. Ryan Mao Fu W. Craig Johnson Michael Tsai Matthew Budoff Ramachandran S. Vasan L. Adrienne Cupples Jerome I. Rotter Stephen S. Rich Wendy Post Braxton D. Mitchell Adolfo Correa Andres Metspalu James G. Wilson Veikko Salomaa Manolis Kellis Mark J. Daly Benjamin M. Neale Steven McCarroll Ida Surakka Tonu Esko Andrea Ganna Samuli Ripatti Sekar Kathiresan Pradeep Natarajan NHLBI TOPMed Lipids Working Group Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries Nature Communications |
| author_facet |
Seyedeh M. Zekavat Sanni Ruotsalainen Robert E. Handsaker Maris Alver Jonathan Bloom Timothy Poterba Cotton Seed Jason Ernst Mark Chaffin Jesse Engreitz Gina M. Peloso Ani Manichaikul Chaojie Yang Kathleen A. Ryan Mao Fu W. Craig Johnson Michael Tsai Matthew Budoff Ramachandran S. Vasan L. Adrienne Cupples Jerome I. Rotter Stephen S. Rich Wendy Post Braxton D. Mitchell Adolfo Correa Andres Metspalu James G. Wilson Veikko Salomaa Manolis Kellis Mark J. Daly Benjamin M. Neale Steven McCarroll Ida Surakka Tonu Esko Andrea Ganna Samuli Ripatti Sekar Kathiresan Pradeep Natarajan NHLBI TOPMed Lipids Working Group |
| author_sort |
Seyedeh M. Zekavat |
| title |
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries |
| title_short |
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries |
| title_full |
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries |
| title_fullStr |
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries |
| title_full_unstemmed |
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries |
| title_sort |
deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of european and african ancestries |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-07-01 |
| description |
Circulating lipoprotein(a) is an important risk factor for cardiovascular disease and shows variability between different ethnic groups. Here, Zekavat et al. perform whole-genome sequencing in individuals of European and African ancestries and find ancestry-specific genetic determinants for lipoprotein(a) levels. |
| url |
https://doi.org/10.1038/s41467-018-04668-w |
| work_keys_str_mv |
AT seyedehmzekavat deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT sanniruotsalainen deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT robertehandsaker deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT marisalver deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT jonathanbloom deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT timothypoterba deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT cottonseed deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT jasonernst deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT markchaffin deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT jesseengreitz deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT ginampeloso deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT animanichaikul deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT chaojieyang deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT kathleenaryan deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT maofu deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT wcraigjohnson deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT michaeltsai deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT matthewbudoff deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT ramachandransvasan deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT ladriennecupples deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT jeromeirotter deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT stephensrich deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT wendypost deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT braxtondmitchell deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT adolfocorrea deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT andresmetspalu deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT jamesgwilson deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT veikkosalomaa deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT manoliskellis deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT markjdaly deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT benjaminmneale deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT stevenmccarroll deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT idasurakka deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT tonuesko deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT andreaganna deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT samuliripatti deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT sekarkathiresan deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT pradeepnatarajan deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries AT nhlbitopmedlipidsworkinggroup deepcoveragewholegenomesequencesandplasmalipoproteinainindividualsofeuropeanandafricanancestries |
| _version_ |
1721449107856293888 |
| spelling |
doaj-dd61e81e8545472a93ddce68c769d81d2021-05-11T09:51:13ZengNature Publishing GroupNature Communications2041-17232018-07-019111410.1038/s41467-018-04668-wDeep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestriesSeyedeh M. Zekavat0Sanni Ruotsalainen1Robert E. Handsaker2Maris Alver3Jonathan Bloom4Timothy Poterba5Cotton Seed6Jason Ernst7Mark Chaffin8Jesse Engreitz9Gina M. Peloso10Ani Manichaikul11Chaojie Yang12Kathleen A. Ryan13Mao Fu14W. Craig Johnson15Michael Tsai16Matthew Budoff17Ramachandran S. Vasan18L. Adrienne Cupples19Jerome I. Rotter20Stephen S. Rich21Wendy Post22Braxton D. Mitchell23Adolfo Correa24Andres Metspalu25James G. Wilson26Veikko Salomaa27Manolis Kellis28Mark J. Daly29Benjamin M. Neale30Steven McCarroll31Ida Surakka32Tonu Esko33Andrea Ganna34Samuli Ripatti35Sekar Kathiresan36Pradeep Natarajan37NHLBI TOPMed Lipids Working GroupProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardInstitute for Molecular Medicine, University of HelsinkiProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardDepartment of Biotechnology, Institute of Molecular and Cell Biology, University of TartuProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardDepartment of Biological Chemistry, University of California, Los AngelesProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardDepartment of Biostatistics, Boston University School of Public HealthCenter for Public Health Genomics, University of VirginiaCenter for Public Health Genomics, University of VirginiaProgram in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Department of Medicine, University of Maryland School of MedicineProgram in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Department of Medicine, University of Maryland School of MedicineDepartment of Biostatistics, School of Public Health and Community Medicine, University of WashingtonDepartment of Laboratory Medicine and Pathology, University of MinnesotaDivision of Cardiology, Harbor-UCLA Medical Center, Los Angeles Biomedical Research InstituteNHLBI Framingham Heart StudyDepartment of Biostatistics, Boston University School of Public HealthDepartments of Pediatrics and Medicine, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical CenterCenter for Public Health Genomics, University of VirginiaDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDepartment of Medicine, University of Maryland School of MedicineDepartment of Medicine, University of Mississippi Medical CenterEstonian Genome CenterDepartment of Medicine, University of Mississippi Medical CenterNational Institute for Health and WelfareProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardInstitute for Molecular Medicine, University of HelsinkiProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardCirculating lipoprotein(a) is an important risk factor for cardiovascular disease and shows variability between different ethnic groups. Here, Zekavat et al. perform whole-genome sequencing in individuals of European and African ancestries and find ancestry-specific genetic determinants for lipoprotein(a) levels.https://doi.org/10.1038/s41467-018-04668-w |