Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife)
Abstract Background Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset and recurrent, severe episodes or a chronic course with poor psychosocial functioning in a proportion of patients. Many patients with BD experience substantial symptomatology months...
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Language: | English |
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SpringerOpen
2020-07-01
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Series: | International Journal of Bipolar Disorders |
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Online Access: | http://link.springer.com/article/10.1186/s40345-020-00183-4 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Pfennig Karolina Leopold Julia Martini Anne Boehme Martin Lambert Thomas Stamm Felix Bermpohl Andreas Reif Sarah Kittel-Schneider Georg Juckel Andreas J. Fallgatter Tilo Kircher Andreas Jansen Steffi Pfeiffer Christina Berndt Maren Rottmann-Wolf Cathrin Sauer Philipp Ritter Christoph U. Correll Andreas Bechdolf Irina Falkenberg Michael Bauer |
spellingShingle |
Andrea Pfennig Karolina Leopold Julia Martini Anne Boehme Martin Lambert Thomas Stamm Felix Bermpohl Andreas Reif Sarah Kittel-Schneider Georg Juckel Andreas J. Fallgatter Tilo Kircher Andreas Jansen Steffi Pfeiffer Christina Berndt Maren Rottmann-Wolf Cathrin Sauer Philipp Ritter Christoph U. Correll Andreas Bechdolf Irina Falkenberg Michael Bauer Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife) International Journal of Bipolar Disorders Bipolar disorder Early recognition Early intervention Risk factor Prevention Antecedent |
author_facet |
Andrea Pfennig Karolina Leopold Julia Martini Anne Boehme Martin Lambert Thomas Stamm Felix Bermpohl Andreas Reif Sarah Kittel-Schneider Georg Juckel Andreas J. Fallgatter Tilo Kircher Andreas Jansen Steffi Pfeiffer Christina Berndt Maren Rottmann-Wolf Cathrin Sauer Philipp Ritter Christoph U. Correll Andreas Bechdolf Irina Falkenberg Michael Bauer |
author_sort |
Andrea Pfennig |
title |
Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife) |
title_short |
Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife) |
title_full |
Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife) |
title_fullStr |
Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife) |
title_full_unstemmed |
Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife) |
title_sort |
improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (early-bipolife) |
publisher |
SpringerOpen |
series |
International Journal of Bipolar Disorders |
issn |
2194-7511 |
publishDate |
2020-07-01 |
description |
Abstract Background Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset and recurrent, severe episodes or a chronic course with poor psychosocial functioning in a proportion of patients. Many patients with BD experience substantial symptomatology months or even years before full BD manifestation. Adequate diagnosis and treatment is often delayed, which is associated with a worse outcome. This study aims to prospectively evaluate and improve early recognition and intervention strategies for persons at-risk for BD. Methods Early-BipoLife is a prospective-longitudinal cohort study of 1419 participants (aged 15–35 years) with at least five waves of assessment over a period of at least 2 years (baseline, 6, 12, 18 and 24 months). A research consortium of ten university and teaching hospitals across Germany conducts this study. The following risk groups (RGs) were recruited: RG I: help-seeking youth and young adults consulting early recognition centres/facilities presenting ≥ 1 of the proposed risk factors for BD, RG II: in-/outpatients with unipolar depressive syndrome, and RG III: in-/outpatients with attention-deficit/hyperactivity disorder (ADHD). The reference cohort was selected from the German representative IMAGEN cohort. Over the study period, the natural course of risk and resilience factors, early symptoms of BD and changes of symptom severity (including conversion to manifest BD) are observed. Psychometric properties of recently developed, structured instruments on potential risk factors for conversion to BD and subsyndromal symptomatology (Bipolar Prodrome Symptom Scale, Bipolar at-risk criteria, EPIbipolar) and biomarkers that potentially improve prediction are investigated. Moreover, actual treatment recommendations are monitored in the participating specialized services and compared to recently postulated clinical categorization and treatment guidance in the field of early BD. Discussion Findings from this study will contribute to an improved knowledge about the natural course of BD, from the onset of first noticeable symptoms (precursors) to fully developed BD, and about mechanisms of conversion from subthreshold to manifest BD. Moreover, these generated data will provide information for the development of evidence-based guidelines for early-targeted detection and preventive intervention for people at risk for BD. |
topic |
Bipolar disorder Early recognition Early intervention Risk factor Prevention Antecedent |
url |
http://link.springer.com/article/10.1186/s40345-020-00183-4 |
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doaj-dd64d884fa4f4b60ad0db156073836222020-11-25T03:01:48ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112020-07-018111410.1186/s40345-020-00183-4Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife)Andrea Pfennig0Karolina Leopold1Julia Martini2Anne Boehme3Martin Lambert4Thomas Stamm5Felix Bermpohl6Andreas Reif7Sarah Kittel-Schneider8Georg Juckel9Andreas J. Fallgatter10Tilo Kircher11Andreas Jansen12Steffi Pfeiffer13Christina Berndt14Maren Rottmann-Wolf15Cathrin Sauer16Philipp Ritter17Christoph U. Correll18Andreas Bechdolf19Irina Falkenberg20Michael Bauer21Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenDepartment of Psychiatry, Psychotherapy and Psychosomatics, Vivantes Klinikum Am UrbanDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-EppendorfDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin BerlinDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin BerlinDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital FrankfurtDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital FrankfurtDepartment of Psychiatry and Psychotherapy, LWL-University Hospital Bochum, Ruhr-University BochumDepartment of General Psychiatry and Psychotherapy, University Hospital TübingenDepartment of Psychiatry and Psychotherapy, University Hospital MarburgDepartment of Psychiatry and Psychotherapy, University Hospital MarburgDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenThe Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, The Zucker Hillside HospitalDepartment of Psychiatry, Psychotherapy and Psychosomatics, Vivantes Klinikum Am UrbanDepartment of Psychiatry and Psychotherapy, University Hospital MarburgDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität DresdenAbstract Background Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset and recurrent, severe episodes or a chronic course with poor psychosocial functioning in a proportion of patients. Many patients with BD experience substantial symptomatology months or even years before full BD manifestation. Adequate diagnosis and treatment is often delayed, which is associated with a worse outcome. This study aims to prospectively evaluate and improve early recognition and intervention strategies for persons at-risk for BD. Methods Early-BipoLife is a prospective-longitudinal cohort study of 1419 participants (aged 15–35 years) with at least five waves of assessment over a period of at least 2 years (baseline, 6, 12, 18 and 24 months). A research consortium of ten university and teaching hospitals across Germany conducts this study. The following risk groups (RGs) were recruited: RG I: help-seeking youth and young adults consulting early recognition centres/facilities presenting ≥ 1 of the proposed risk factors for BD, RG II: in-/outpatients with unipolar depressive syndrome, and RG III: in-/outpatients with attention-deficit/hyperactivity disorder (ADHD). The reference cohort was selected from the German representative IMAGEN cohort. Over the study period, the natural course of risk and resilience factors, early symptoms of BD and changes of symptom severity (including conversion to manifest BD) are observed. Psychometric properties of recently developed, structured instruments on potential risk factors for conversion to BD and subsyndromal symptomatology (Bipolar Prodrome Symptom Scale, Bipolar at-risk criteria, EPIbipolar) and biomarkers that potentially improve prediction are investigated. Moreover, actual treatment recommendations are monitored in the participating specialized services and compared to recently postulated clinical categorization and treatment guidance in the field of early BD. Discussion Findings from this study will contribute to an improved knowledge about the natural course of BD, from the onset of first noticeable symptoms (precursors) to fully developed BD, and about mechanisms of conversion from subthreshold to manifest BD. Moreover, these generated data will provide information for the development of evidence-based guidelines for early-targeted detection and preventive intervention for people at risk for BD.http://link.springer.com/article/10.1186/s40345-020-00183-4Bipolar disorderEarly recognitionEarly interventionRisk factorPreventionAntecedent |