Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-co...

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Bibliographic Details
Main Author: Gethin J. McBean
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Antioxidants
Subjects:
cysteine
cystine
cysteamine
cystathionine
glutathione
xc− cystine-glutamate exchanger
transsulfuration
Online Access:https://www.mdpi.com/2076-3921/6/3/62
Description
Summary:This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-containing amino acid metabolism on the antioxidant capacity of astrocytes is also discussed.
ISSN:2076-3921

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