Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns.
Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial birth defect in humans-and dermatoglyphics is incons...
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doaj-dd806ce1c31549b188c19881c86818ad2021-04-14T04:30:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01153e023053410.1371/journal.pone.0230534Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns.Katherine NeiswangerNandita MukhopadhyayShwetha RajagopalanElizabeth J LeslieCarla A SanchezJacqueline T HechtIêda M OrioliFernando A PolettaJavier Enríquez de SalamancaSeth M WeinbergMary L MarazitaDermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial birth defect in humans-and dermatoglyphics is inconsistent, with some studies reporting altered pattern frequencies and/or increased asymmetry and others failing to find differences. To investigate dermatoglyphics in orofacial clefting, we obtained dermatoglyphic patterns in a large multiethnic cohort of orofacial cleft cases (N = 367), their unaffected family members (N = 836), and controls (N = 299). We categorized fingerprint pattern types from males and females who participated at five sites of the Pittsburgh Orofacial Cleft study (Hungary, United States of America (Pennsylvania, Texas), Spain, and Argentina). We also calculated a pattern dissimilarity score for each individual as a measure of left-right asymmetry. We tested for group differences in the number of arches, ulnar and radial loops, and whorls on each individual's hands, and in the pattern dissimilarity scores using ANOVA. After taking sex and site differences into account, we did not find any significant pattern count differences between cleft and non-cleft individuals. Notably, we did observe increased pattern dissimilarity in individuals with clefts, compared to both their unaffected relatives and controls. Increased dermatoglyphic pattern dissimilarity in individuals with nonsyndromic orofacial clefts may reflect a generalized developmental instability.https://doi.org/10.1371/journal.pone.0230534 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katherine Neiswanger Nandita Mukhopadhyay Shwetha Rajagopalan Elizabeth J Leslie Carla A Sanchez Jacqueline T Hecht Iêda M Orioli Fernando A Poletta Javier Enríquez de Salamanca Seth M Weinberg Mary L Marazita |
spellingShingle |
Katherine Neiswanger Nandita Mukhopadhyay Shwetha Rajagopalan Elizabeth J Leslie Carla A Sanchez Jacqueline T Hecht Iêda M Orioli Fernando A Poletta Javier Enríquez de Salamanca Seth M Weinberg Mary L Marazita Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns. PLoS ONE |
author_facet |
Katherine Neiswanger Nandita Mukhopadhyay Shwetha Rajagopalan Elizabeth J Leslie Carla A Sanchez Jacqueline T Hecht Iêda M Orioli Fernando A Poletta Javier Enríquez de Salamanca Seth M Weinberg Mary L Marazita |
author_sort |
Katherine Neiswanger |
title |
Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns. |
title_short |
Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns. |
title_full |
Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns. |
title_fullStr |
Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns. |
title_full_unstemmed |
Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns. |
title_sort |
individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2020-01-01 |
description |
Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial birth defect in humans-and dermatoglyphics is inconsistent, with some studies reporting altered pattern frequencies and/or increased asymmetry and others failing to find differences. To investigate dermatoglyphics in orofacial clefting, we obtained dermatoglyphic patterns in a large multiethnic cohort of orofacial cleft cases (N = 367), their unaffected family members (N = 836), and controls (N = 299). We categorized fingerprint pattern types from males and females who participated at five sites of the Pittsburgh Orofacial Cleft study (Hungary, United States of America (Pennsylvania, Texas), Spain, and Argentina). We also calculated a pattern dissimilarity score for each individual as a measure of left-right asymmetry. We tested for group differences in the number of arches, ulnar and radial loops, and whorls on each individual's hands, and in the pattern dissimilarity scores using ANOVA. After taking sex and site differences into account, we did not find any significant pattern count differences between cleft and non-cleft individuals. Notably, we did observe increased pattern dissimilarity in individuals with clefts, compared to both their unaffected relatives and controls. Increased dermatoglyphic pattern dissimilarity in individuals with nonsyndromic orofacial clefts may reflect a generalized developmental instability. |
url |
https://doi.org/10.1371/journal.pone.0230534 |
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