Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases

• Main Authors: Anqi Zhou, Bingfeng Wu, Hui Yu, Yufei Tang, Jiayi Liu, Yinan Jia, Xiaoyu Yang, Lin Xiang
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-08-01
• Series: Frontiers in Cell and Developmental Biology
• Subjects: osteoimmunology; RANKL/RANK/OPG; rheumatoid arthritis; periodontitis; bone repair; dental implantation
• Online Access: https://www.frontiersin.org/articles/10.3389/fcell.2021.698068/full

The skeletal system and immune system seem to be two independent systems. However, there in fact are extensive and multiple crosstalk between them. The concept of osteoimmunology was created to describe those interdisciplinary events, but it has been constantly updated over time. In this review, we summarize the interactions between the skeletal and immune systems in the co-development of the two systems and the progress of certain typical bone abnormalities and bone regeneration on the cellular and molecular levels according to the mainstream novel study. At the end of the review, we also highlighted the possibility of extending the research scope of osteoimmunology to other systemic diseases. In conclusion, we propose that osteoimmunology is a promising perspective to uncover the mechanism of related diseases; meanwhile, a study from the point of view of osteoimmunology may also provide innovative ideas and resolutions to achieve the balance of internal homeostasis.