Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases
Cardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine recep...
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Online Access: | http://www.mdpi.com/1420-3049/22/6/917 |
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doaj-dd88349ba402402c93ec63d887b2c5fc2020-11-24T20:59:22ZengMDPI AGMolecules1420-30492017-06-0122691710.3390/molecules22060917molecules22060917Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular DiseasesWerner J. Geldenhuys0Ahmad Hanif1June Yun2Mohammed A. Nayeem3Department of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, USADepartment of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, USADepartment of Integrative Medical Sciences, Northeast Ohio Medical University College of Medicine, Rootstown, OH 44272, USADepartment of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, USACardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine receptors have been connected to several biological pathways affecting the physiology and pathology of the cardiovascular system. In this review, we will cover the different adenosine receptor ligands that have been identified to interact with adenosine receptors and affect the vascular system. These ligands will be evaluated from clinical as well as medicinal chemistry perspectives with more emphasis on how structural changes in structure translate into ligand potency and efficacy. Adenosine receptors represent a novel therapeutic target for development of treatment options treating a wide variety of diseases, including vascular disease and obesity.http://www.mdpi.com/1420-3049/22/6/917atherosclerosismyocardial infarctioncardiac deathvascular tone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Werner J. Geldenhuys Ahmad Hanif June Yun Mohammed A. Nayeem |
spellingShingle |
Werner J. Geldenhuys Ahmad Hanif June Yun Mohammed A. Nayeem Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases Molecules atherosclerosis myocardial infarction cardiac death vascular tone |
author_facet |
Werner J. Geldenhuys Ahmad Hanif June Yun Mohammed A. Nayeem |
author_sort |
Werner J. Geldenhuys |
title |
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases |
title_short |
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases |
title_full |
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases |
title_fullStr |
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases |
title_full_unstemmed |
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases |
title_sort |
exploring adenosine receptor ligands: potential role in the treatment of cardiovascular diseases |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-06-01 |
description |
Cardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine receptors have been connected to several biological pathways affecting the physiology and pathology of the cardiovascular system. In this review, we will cover the different adenosine receptor ligands that have been identified to interact with adenosine receptors and affect the vascular system. These ligands will be evaluated from clinical as well as medicinal chemistry perspectives with more emphasis on how structural changes in structure translate into ligand potency and efficacy. Adenosine receptors represent a novel therapeutic target for development of treatment options treating a wide variety of diseases, including vascular disease and obesity. |
topic |
atherosclerosis myocardial infarction cardiac death vascular tone |
url |
http://www.mdpi.com/1420-3049/22/6/917 |
work_keys_str_mv |
AT wernerjgeldenhuys exploringadenosinereceptorligandspotentialroleinthetreatmentofcardiovasculardiseases AT ahmadhanif exploringadenosinereceptorligandspotentialroleinthetreatmentofcardiovasculardiseases AT juneyun exploringadenosinereceptorligandspotentialroleinthetreatmentofcardiovasculardiseases AT mohammedanayeem exploringadenosinereceptorligandspotentialroleinthetreatmentofcardiovasculardiseases |
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1716782713453674496 |