Urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in Tanzania and Uganda
Background: The increase in prevalence of diabetes and pre-diabetes in sub-Saharan Africa underlines the importance of understanding its magnitude and causes in different population groups. We analyzed data from the Africa/Harvard Partnership for Cohort Research and Training (PaCT) studies to determ...
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doaj-dda4a502b5384fe5846f86f9f1fe4a442020-11-24T22:57:46ZengTaylor & Francis GroupGlobal Health Action1654-98802016-05-01901810.3402/gha.v9.3144031440Urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in Tanzania and UgandaFaraja S. Chiwanga0Marina A. Njelekela1Megan B. Diamond2Francis Bajunirwe3David Guwatudde4Joan Nankya-Mutyoba5Robert Kalyesubula6Clement Adebamowo7IkeOluwapo Ajayi8Todd G. Reid9Jimmy Volmink10Carien Laurence11Hans-Olov Adami12Michelle D. Holmes13Shona Dalal14 Endocrinology and Diabetes Unit, Department of Internal Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania Department of Physiology, Faculty of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda Department of Epidemiology and Biostatistics, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda Department of Epidemiology and Biostatistics, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda Department of Epidemiology and Biostatistics, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda Institute of Human Virology, Abuja, Nigeria Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA The South African Cochrane Centre, South African Medical Research Council, Cape Town, South Africa Centre for Evidence-based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USABackground: The increase in prevalence of diabetes and pre-diabetes in sub-Saharan Africa underlines the importance of understanding its magnitude and causes in different population groups. We analyzed data from the Africa/Harvard Partnership for Cohort Research and Training (PaCT) studies to determine the prevalence of diabetes and pre-diabetes and risk factors associated with diabetes. Methodology: Participants were randomly selected from peri-urban (n=297) and rural (n=200) communities in Uganda, and teachers were recruited from schools (n=229) in urban Tanzania. We used a standardized questionnaire to collect socio-demographic and self-reported disease status including diabetes status. Blood glucose was also measured after participants fasted for 8 h. We used standard protocols for anthropometric and blood pressure measurement. Results: The overall prevalence of diabetes was 10.1% and was highest in rural Ugandan residents (16.1%) compared to teachers in Tanzania (8.3%) and peri-urban Ugandan residents (7.6%). The prevalence of pre-diabetes was 13.8%. The prevalence of self-reported diabetes was low across all sites, where 68% of participants with diabetes were not captured by self-report. In multivariable logistic regression analysis, family history (OR 2.5, 95% CI: 1.1, 5.6) and hypertension (OR 2.3, 95% CI: 1.1, 5.2) were significantly associated with diabetes. Conclusions: The prevalence of diabetes and pre-diabetes in Uganda and Tanzania is high, differs markedly between population groups, and remains undiagnosed in an alarmingly high proportion of individuals. These findings highlight the need for large-scale, prospective studies to accurately quantify the burden and identify effective intervention and treatment strategies across diverse African populations.http://www.globalhealthaction.net/index.php/gha/article/view/31440/pdf_202non-communicablerisk factorsunderdiagnosessub-Saharan AfricaTanzaniaUganda |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Faraja S. Chiwanga Marina A. Njelekela Megan B. Diamond Francis Bajunirwe David Guwatudde Joan Nankya-Mutyoba Robert Kalyesubula Clement Adebamowo IkeOluwapo Ajayi Todd G. Reid Jimmy Volmink Carien Laurence Hans-Olov Adami Michelle D. Holmes Shona Dalal |
spellingShingle |
Faraja S. Chiwanga Marina A. Njelekela Megan B. Diamond Francis Bajunirwe David Guwatudde Joan Nankya-Mutyoba Robert Kalyesubula Clement Adebamowo IkeOluwapo Ajayi Todd G. Reid Jimmy Volmink Carien Laurence Hans-Olov Adami Michelle D. Holmes Shona Dalal Urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in Tanzania and Uganda Global Health Action non-communicable risk factors underdiagnoses sub-Saharan Africa Tanzania Uganda |
author_facet |
Faraja S. Chiwanga Marina A. Njelekela Megan B. Diamond Francis Bajunirwe David Guwatudde Joan Nankya-Mutyoba Robert Kalyesubula Clement Adebamowo IkeOluwapo Ajayi Todd G. Reid Jimmy Volmink Carien Laurence Hans-Olov Adami Michelle D. Holmes Shona Dalal |
author_sort |
Faraja S. Chiwanga |
title |
Urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in Tanzania and Uganda |
title_short |
Urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in Tanzania and Uganda |
title_full |
Urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in Tanzania and Uganda |
title_fullStr |
Urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in Tanzania and Uganda |
title_full_unstemmed |
Urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in Tanzania and Uganda |
title_sort |
urban and rural prevalence of diabetes and pre-diabetes and risk factors associated with diabetes in tanzania and uganda |
publisher |
Taylor & Francis Group |
series |
Global Health Action |
issn |
1654-9880 |
publishDate |
2016-05-01 |
description |
Background: The increase in prevalence of diabetes and pre-diabetes in sub-Saharan Africa underlines the importance of understanding its magnitude and causes in different population groups. We analyzed data from the Africa/Harvard Partnership for Cohort Research and Training (PaCT) studies to determine the prevalence of diabetes and pre-diabetes and risk factors associated with diabetes. Methodology: Participants were randomly selected from peri-urban (n=297) and rural (n=200) communities in Uganda, and teachers were recruited from schools (n=229) in urban Tanzania. We used a standardized questionnaire to collect socio-demographic and self-reported disease status including diabetes status. Blood glucose was also measured after participants fasted for 8 h. We used standard protocols for anthropometric and blood pressure measurement. Results: The overall prevalence of diabetes was 10.1% and was highest in rural Ugandan residents (16.1%) compared to teachers in Tanzania (8.3%) and peri-urban Ugandan residents (7.6%). The prevalence of pre-diabetes was 13.8%. The prevalence of self-reported diabetes was low across all sites, where 68% of participants with diabetes were not captured by self-report. In multivariable logistic regression analysis, family history (OR 2.5, 95% CI: 1.1, 5.6) and hypertension (OR 2.3, 95% CI: 1.1, 5.2) were significantly associated with diabetes. Conclusions: The prevalence of diabetes and pre-diabetes in Uganda and Tanzania is high, differs markedly between population groups, and remains undiagnosed in an alarmingly high proportion of individuals. These findings highlight the need for large-scale, prospective studies to accurately quantify the burden and identify effective intervention and treatment strategies across diverse African populations. |
topic |
non-communicable risk factors underdiagnoses sub-Saharan Africa Tanzania Uganda |
url |
http://www.globalhealthaction.net/index.php/gha/article/view/31440/pdf_202 |
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