Hepatitis C virus infection in patients with primary biliary cirrhosis
Background and aim. The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC).Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection betw...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2013-01-01
|
Series: | Annals of Hepatology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119313882 |
id |
doaj-dda8d9e1229a4d24a2fd1dbc3932adb1 |
---|---|
record_format |
Article |
spelling |
doaj-dda8d9e1229a4d24a2fd1dbc3932adb12021-06-09T05:54:26ZengElsevierAnnals of Hepatology1665-26812013-01-011217884Hepatitis C virus infection in patients with primary biliary cirrhosisHsuan-Wei Chen0Hsin-Hung Huang1Ching-Huang Lai2Wei-En Chang3Yu-Lueng Shih4Wei-Kuo Chang5Tsai-Yuan Hsieh6Heng-Cheng Chu7Division of Gastroenterology & Hepatology, Tri-Service General Hospital, National Defense Medical Center, Taiwan.Division of Gastroenterology & Hepatology, Tri-Service General Hospital, National Defense Medical Center, Taiwan.School of Public Health, National Defense Medical Center, Taiwan.Department of Internal Medicine, Hualien Armed Forces General Hospital, Taiwan.Division of Gastroenterology & Hepatology, Tri-Service General Hospital, National Defense Medical Center, Taiwan.Division of Gastroenterology & Hepatology, Tri-Service General Hospital, National Defense Medical Center, Taiwan.Division of Gastroenterology & Hepatology, Tri-Service General Hospital, National Defense Medical Center, Taiwan.Division of Gastroenterology & Hepatology, Tri-Service General Hospital, National Defense Medical Center, Taiwan.; Corresponding author.Background and aim. The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC).Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study. Clinical characteristics, especially the severity of cirrhosis, were analyzed in PBC patients with HCV infection (PBC-HCV), PBC patients without HCV infection (PBC-only), and patients with only HCV infection (HCV-only).Results. A total of 76 patients with PBC, including 9 patients with HCV infection, were analyzed. Of the PBC-HCV patients, 7 (7/9, 77.8%) were women with a mean age of 55.11 ± 14.29 years. Age- and sex-matched PBC-only patients (n = 36) and HCV-only patients (n = 36) were used as control groups. In comparison to the PBC-only controls, PBC-HCV patients had a greater severity of cirrhosis based on Child-Pugh (p = 0.019) and Model for End-Stage Liver Disease (MELD) (p = 0.01) scores. However, no significant difference in the severity of cirrhosis was found between the PBC-HCV and HCV-only control patients (p = 0.94 in Child-Pugh scores; p = 0.64 in MELD scores).Conclusions. In PBC patients with concomitant HCV infection, aggressive management may be warranted in view of the associated more severe liver cirrhosis.http://www.sciencedirect.com/science/article/pii/S1665268119313882Child-Pugh scoreMELD scoreCirrhosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsuan-Wei Chen Hsin-Hung Huang Ching-Huang Lai Wei-En Chang Yu-Lueng Shih Wei-Kuo Chang Tsai-Yuan Hsieh Heng-Cheng Chu |
spellingShingle |
Hsuan-Wei Chen Hsin-Hung Huang Ching-Huang Lai Wei-En Chang Yu-Lueng Shih Wei-Kuo Chang Tsai-Yuan Hsieh Heng-Cheng Chu Hepatitis C virus infection in patients with primary biliary cirrhosis Annals of Hepatology Child-Pugh score MELD score Cirrhosis |
author_facet |
Hsuan-Wei Chen Hsin-Hung Huang Ching-Huang Lai Wei-En Chang Yu-Lueng Shih Wei-Kuo Chang Tsai-Yuan Hsieh Heng-Cheng Chu |
author_sort |
Hsuan-Wei Chen |
title |
Hepatitis C virus infection in patients with primary biliary cirrhosis |
title_short |
Hepatitis C virus infection in patients with primary biliary cirrhosis |
title_full |
Hepatitis C virus infection in patients with primary biliary cirrhosis |
title_fullStr |
Hepatitis C virus infection in patients with primary biliary cirrhosis |
title_full_unstemmed |
Hepatitis C virus infection in patients with primary biliary cirrhosis |
title_sort |
hepatitis c virus infection in patients with primary biliary cirrhosis |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2013-01-01 |
description |
Background and aim. The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC).Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study. Clinical characteristics, especially the severity of cirrhosis, were analyzed in PBC patients with HCV infection (PBC-HCV), PBC patients without HCV infection (PBC-only), and patients with only HCV infection (HCV-only).Results. A total of 76 patients with PBC, including 9 patients with HCV infection, were analyzed. Of the PBC-HCV patients, 7 (7/9, 77.8%) were women with a mean age of 55.11 ± 14.29 years. Age- and sex-matched PBC-only patients (n = 36) and HCV-only patients (n = 36) were used as control groups. In comparison to the PBC-only controls, PBC-HCV patients had a greater severity of cirrhosis based on Child-Pugh (p = 0.019) and Model for End-Stage Liver Disease (MELD) (p = 0.01) scores. However, no significant difference in the severity of cirrhosis was found between the PBC-HCV and HCV-only control patients (p = 0.94 in Child-Pugh scores; p = 0.64 in MELD scores).Conclusions. In PBC patients with concomitant HCV infection, aggressive management may be warranted in view of the associated more severe liver cirrhosis. |
topic |
Child-Pugh score MELD score Cirrhosis |
url |
http://www.sciencedirect.com/science/article/pii/S1665268119313882 |
work_keys_str_mv |
AT hsuanweichen hepatitiscvirusinfectioninpatientswithprimarybiliarycirrhosis AT hsinhunghuang hepatitiscvirusinfectioninpatientswithprimarybiliarycirrhosis AT chinghuanglai hepatitiscvirusinfectioninpatientswithprimarybiliarycirrhosis AT weienchang hepatitiscvirusinfectioninpatientswithprimarybiliarycirrhosis AT yuluengshih hepatitiscvirusinfectioninpatientswithprimarybiliarycirrhosis AT weikuochang hepatitiscvirusinfectioninpatientswithprimarybiliarycirrhosis AT tsaiyuanhsieh hepatitiscvirusinfectioninpatientswithprimarybiliarycirrhosis AT hengchengchu hepatitiscvirusinfectioninpatientswithprimarybiliarycirrhosis |
_version_ |
1721388777591537664 |