KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation

KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation

Genomic loops and their temporal dynamics play an important role in gene expression of DNA viruses, but are incompletely understood. Here, the authors use capture Hi-C analyses and identify genomic architectural dynamics of KSHV that are regulated by the viral transactivator K-Rta.

Bibliographic Details
Main Authors: Mel Campbell, Tadashi Watanabe, Kazushi Nakano, Ryan R. Davis, Yuanzhi Lyu, Clifford G. Tepper, Blythe Durbin-Johnson, Masahiro Fujimuro, Yoshihiro Izumiya
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02089-9
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spelling doaj-dda9944922624a1d8b1fe07d7ee176f62021-05-11T09:59:20ZengNature Publishing GroupNature Communications2041-17232018-01-019111410.1038/s41467-017-02089-9KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulationMel Campbell0Tadashi Watanabe1Kazushi Nakano2Ryan R. Davis3Yuanzhi Lyu4Clifford G. Tepper5Blythe Durbin-Johnson6Masahiro Fujimuro7Yoshihiro Izumiya8Department of Dermatology, School of Medicine, University of California Davis (UC Davis)Department of Cell Biology, Kyoto Pharmaceutical UniversityDepartment of Dermatology, School of Medicine, University of California Davis (UC Davis)Department of Pathology and Laboratory Medicine, School of Medicine, UC DavisDepartment of Dermatology, School of Medicine, University of California Davis (UC Davis)Department of Biochemistry and Molecular Medicine, UC Davis School of MedicineDivision of Biostatistics, Department of Public Health Sciences, UC Davis School of MedicineDepartment of Cell Biology, Kyoto Pharmaceutical UniversityDepartment of Dermatology, School of Medicine, University of California Davis (UC Davis)Genomic loops and their temporal dynamics play an important role in gene expression of DNA viruses, but are incompletely understood. Here, the authors use capture Hi-C analyses and identify genomic architectural dynamics of KSHV that are regulated by the viral transactivator K-Rta.https://doi.org/10.1038/s41467-017-02089-9
collection DOAJ
language English
format Article
sources DOAJ
author Mel Campbell
Tadashi Watanabe
Kazushi Nakano
Ryan R. Davis
Yuanzhi Lyu
Clifford G. Tepper
Blythe Durbin-Johnson
Masahiro Fujimuro
Yoshihiro Izumiya
spellingShingle Mel Campbell
Tadashi Watanabe
Kazushi Nakano
Ryan R. Davis
Yuanzhi Lyu
Clifford G. Tepper
Blythe Durbin-Johnson
Masahiro Fujimuro
Yoshihiro Izumiya
KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
Nature Communications
author_facet Mel Campbell
Tadashi Watanabe
Kazushi Nakano
Ryan R. Davis
Yuanzhi Lyu
Clifford G. Tepper
Blythe Durbin-Johnson
Masahiro Fujimuro
Yoshihiro Izumiya
author_sort Mel Campbell
title KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_short KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_full KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_fullStr KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_full_unstemmed KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_sort kshv episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description Genomic loops and their temporal dynamics play an important role in gene expression of DNA viruses, but are incompletely understood. Here, the authors use capture Hi-C analyses and identify genomic architectural dynamics of KSHV that are regulated by the viral transactivator K-Rta.
url https://doi.org/10.1038/s41467-017-02089-9
work_keys_str_mv AT melcampbell kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
AT tadashiwatanabe kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
AT kazushinakano kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
AT ryanrdavis kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
AT yuanzhilyu kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
AT cliffordgtepper kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
AT blythedurbinjohnson kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
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AT yoshihiroizumiya kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
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