Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism
Pleuroparenchymal fibroelastosis (PPFE) is a newly described entity of interstitial lung disease, which has been recently recognized as a rare complication of bone marrow transplantation. We report a case of 30-year-old man who developed a unique combination of pleuroparenchymal fibroelastosis with...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-01-01
|
Series: | Respiratory Medicine Case Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007118303988 |
id |
doaj-ddacf71ab30f48c783c07d498c7099a1 |
---|---|
record_format |
Article |
spelling |
doaj-ddacf71ab30f48c783c07d498c7099a12020-11-25T00:57:41ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-0126244247Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanismZun Pwint Oo0Andrey Bychkov1Yoshiaki Zaizen2Mari Yamasue3Jun-ichi Kadota4Junya Fukuoka5Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan; Department of Pathology, University of Medicine, Mandalay, MyanmarDepartment of Pathology, Kameda Medical Center, Kamogawa, Chiba, Japan; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Pathology, Nagasaki University Hospital, Nagasaki, JapanOita University Hospital, Oita, JapanDepartment of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, Oita, JapanDepartment of Pathology, Nagasaki University Hospital, Nagasaki, Japan; Department of Pathology, Kameda Medical Center, Kamogawa, Chiba, Japan; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Corresponding author. Department of Pathology, Nagasaki University Hospital, 1-7-1, Sakamoto, Nagasaki, 852-8523, Japan.Pleuroparenchymal fibroelastosis (PPFE) is a newly described entity of interstitial lung disease, which has been recently recognized as a rare complication of bone marrow transplantation. We report a case of 30-year-old man who developed a unique combination of pleuroparenchymal fibroelastosis with cellular and fibrotic non-specific interstitial pneumonia (NSIP) and bronchiolitis obliterans (BO) sixteen years after hematopoietic stem cell transplantation. Histological examination revealed almost exclusive infiltration of CD3-positive T lymphocytes associated with lymphoepithelial lesions and multi-focal denudation of covering epithelial cells in all components. This case suggests PPFE, NSIP, and BO might be conditions of the same spectrum, pathogenetically related to chronic graft-versus-host disease. Immunostaining for CD3 and CD20 in transbronchial lung biopsies may be helpful for identifying graft-versus-host-driven interstitial lung disease. Keywords: Graft-versus-host disease, HRCT, Interstitial lung disease, Pathology, Pulmonary fibroelastosishttp://www.sciencedirect.com/science/article/pii/S2213007118303988 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zun Pwint Oo Andrey Bychkov Yoshiaki Zaizen Mari Yamasue Jun-ichi Kadota Junya Fukuoka |
spellingShingle |
Zun Pwint Oo Andrey Bychkov Yoshiaki Zaizen Mari Yamasue Jun-ichi Kadota Junya Fukuoka Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism Respiratory Medicine Case Reports |
author_facet |
Zun Pwint Oo Andrey Bychkov Yoshiaki Zaizen Mari Yamasue Jun-ichi Kadota Junya Fukuoka |
author_sort |
Zun Pwint Oo |
title |
Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism |
title_short |
Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism |
title_full |
Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism |
title_fullStr |
Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism |
title_full_unstemmed |
Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism |
title_sort |
combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — clues to a potential mechanism |
publisher |
Elsevier |
series |
Respiratory Medicine Case Reports |
issn |
2213-0071 |
publishDate |
2019-01-01 |
description |
Pleuroparenchymal fibroelastosis (PPFE) is a newly described entity of interstitial lung disease, which has been recently recognized as a rare complication of bone marrow transplantation. We report a case of 30-year-old man who developed a unique combination of pleuroparenchymal fibroelastosis with cellular and fibrotic non-specific interstitial pneumonia (NSIP) and bronchiolitis obliterans (BO) sixteen years after hematopoietic stem cell transplantation. Histological examination revealed almost exclusive infiltration of CD3-positive T lymphocytes associated with lymphoepithelial lesions and multi-focal denudation of covering epithelial cells in all components. This case suggests PPFE, NSIP, and BO might be conditions of the same spectrum, pathogenetically related to chronic graft-versus-host disease. Immunostaining for CD3 and CD20 in transbronchial lung biopsies may be helpful for identifying graft-versus-host-driven interstitial lung disease. Keywords: Graft-versus-host disease, HRCT, Interstitial lung disease, Pathology, Pulmonary fibroelastosis |
url |
http://www.sciencedirect.com/science/article/pii/S2213007118303988 |
work_keys_str_mv |
AT zunpwintoo combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism AT andreybychkov combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism AT yoshiakizaizen combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism AT mariyamasue combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism AT junichikadota combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism AT junyafukuoka combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism |
_version_ |
1725222800165175296 |