Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism

Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism

Pleuroparenchymal fibroelastosis (PPFE) is a newly described entity of interstitial lung disease, which has been recently recognized as a rare complication of bone marrow transplantation. We report a case of 30-year-old man who developed a unique combination of pleuroparenchymal fibroelastosis with...

Full description

Bibliographic Details
Main Authors: Zun Pwint Oo, Andrey Bychkov, Yoshiaki Zaizen, Mari Yamasue, Jun-ichi Kadota, Junya Fukuoka
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Respiratory Medicine Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213007118303988
id doaj-ddacf71ab30f48c783c07d498c7099a1
record_format Article
spelling doaj-ddacf71ab30f48c783c07d498c7099a12020-11-25T00:57:41ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-0126244247Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanismZun Pwint Oo0Andrey Bychkov1Yoshiaki Zaizen2Mari Yamasue3Jun-ichi Kadota4Junya Fukuoka5Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan; Department of Pathology, University of Medicine, Mandalay, MyanmarDepartment of Pathology, Kameda Medical Center, Kamogawa, Chiba, Japan; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Pathology, Nagasaki University Hospital, Nagasaki, JapanOita University Hospital, Oita, JapanDepartment of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, Oita, JapanDepartment of Pathology, Nagasaki University Hospital, Nagasaki, Japan; Department of Pathology, Kameda Medical Center, Kamogawa, Chiba, Japan; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Corresponding author. Department of Pathology, Nagasaki University Hospital, 1-7-1, Sakamoto, Nagasaki, 852-8523, Japan.Pleuroparenchymal fibroelastosis (PPFE) is a newly described entity of interstitial lung disease, which has been recently recognized as a rare complication of bone marrow transplantation. We report a case of 30-year-old man who developed a unique combination of pleuroparenchymal fibroelastosis with cellular and fibrotic non-specific interstitial pneumonia (NSIP) and bronchiolitis obliterans (BO) sixteen years after hematopoietic stem cell transplantation. Histological examination revealed almost exclusive infiltration of CD3-positive T lymphocytes associated with lymphoepithelial lesions and multi-focal denudation of covering epithelial cells in all components. This case suggests PPFE, NSIP, and BO might be conditions of the same spectrum, pathogenetically related to chronic graft-versus-host disease. Immunostaining for CD3 and CD20 in transbronchial lung biopsies may be helpful for identifying graft-versus-host-driven interstitial lung disease. Keywords: Graft-versus-host disease, HRCT, Interstitial lung disease, Pathology, Pulmonary fibroelastosishttp://www.sciencedirect.com/science/article/pii/S2213007118303988
collection DOAJ
language English
format Article
sources DOAJ
author Zun Pwint Oo
Andrey Bychkov
Yoshiaki Zaizen
Mari Yamasue
Jun-ichi Kadota
Junya Fukuoka
spellingShingle Zun Pwint Oo
Andrey Bychkov
Yoshiaki Zaizen
Mari Yamasue
Jun-ichi Kadota
Junya Fukuoka
Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism
Respiratory Medicine Case Reports
author_facet Zun Pwint Oo
Andrey Bychkov
Yoshiaki Zaizen
Mari Yamasue
Jun-ichi Kadota
Junya Fukuoka
author_sort Zun Pwint Oo
title Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism
title_short Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism
title_full Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism
title_fullStr Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism
title_full_unstemmed Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism
title_sort combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — clues to a potential mechanism
publisher Elsevier
series Respiratory Medicine Case Reports
issn 2213-0071
publishDate 2019-01-01
description Pleuroparenchymal fibroelastosis (PPFE) is a newly described entity of interstitial lung disease, which has been recently recognized as a rare complication of bone marrow transplantation. We report a case of 30-year-old man who developed a unique combination of pleuroparenchymal fibroelastosis with cellular and fibrotic non-specific interstitial pneumonia (NSIP) and bronchiolitis obliterans (BO) sixteen years after hematopoietic stem cell transplantation. Histological examination revealed almost exclusive infiltration of CD3-positive T lymphocytes associated with lymphoepithelial lesions and multi-focal denudation of covering epithelial cells in all components. This case suggests PPFE, NSIP, and BO might be conditions of the same spectrum, pathogenetically related to chronic graft-versus-host disease. Immunostaining for CD3 and CD20 in transbronchial lung biopsies may be helpful for identifying graft-versus-host-driven interstitial lung disease. Keywords: Graft-versus-host disease, HRCT, Interstitial lung disease, Pathology, Pulmonary fibroelastosis
url http://www.sciencedirect.com/science/article/pii/S2213007118303988
work_keys_str_mv AT zunpwintoo combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism
AT andreybychkov combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism
AT yoshiakizaizen combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism
AT mariyamasue combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism
AT junichikadota combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism
AT junyafukuoka combinationofpleuroparenchymalfibroelastosiswithnonspecificinterstitialpneumoniaandbronchiolitisobliteransasacomplicationofhematopoieticstemcelltransplantationcluestoapotentialmechanism
_version_ 1725222800165175296

Similar Items