HIV prevalence in suspected Ebola cases during the 2014–2016 Ebola epidemic in Sierra Leone
Abstract Background The 2014–2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease (EVD) in history. Clarifying the influence of other prevalent diseases such as human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) will help imp...
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doaj-ddaed50b198a49e7bfcc7126aabb62412020-11-24T22:11:30ZengBMCInfectious Diseases of Poverty2049-99572019-03-01811410.1186/s40249-019-0525-9HIV prevalence in suspected Ebola cases during the 2014–2016 Ebola epidemic in Sierra LeoneWilliam J. Liu0Hai-Yang Hu1Qiu-Dong Su2Zhe Zhang3Yang Liu4Yu-Lan Sun5Xian-Da Yang6Da-Peng Sun7Shao-Jian Cai8Xiu-Xu Yang9Idrissa Kamara10Abdul Kamara11Matt Lebby12Brima Kargbo13Patricia Ongpin14Xiao-Ping Dong15Yue-Long Shu16Wen-Bo Xu17Gui-Zhen Wu18Michael Gboun19George F. Gao20NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC)Jiangsu Provincial Center for Disease control and PreventionNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC)Beijing Institute of BiotechnologyNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC)Beijing Center for Disease Prevention and ControlJilin Provincial Center for Disease control and PreventionShandong Provincial Center for Disease control and PreventionFujian Provincial Center for Disease control and PreventionBeijing Institute of BiotechnologyThe Ministry of Health and SanitationThe Ministry of Health and SanitationThe Ministry of Health and SanitationThe Ministry of Health and SanitationUNAIDSNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC)NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC)NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC)NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC)UNAIDSNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC)Abstract Background The 2014–2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease (EVD) in history. Clarifying the influence of other prevalent diseases such as human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) will help improve treatment and supportive care of patients with EVD. Case presentation We examined HIV and hepatitis C virus (HCV) antibody prevalence among suspected EVD cases from the Sierra Leone-China Friendship Biological Safety Laboratory during the epidemic in Sierra Leone. HIV and HCV antibodies were tested in 678 EVD-negative samples by enzyme-linked immunosorbent assay. A high HIV prevalence (17.6%) and low HCV prevalence (0.22%) were observed among the suspected cases. Notably, we found decreased HIV positive rates among the suspected cases over the course of the epidemic. This suggests a potentially beneficial effect of an improved public health system after assistance from the World Health Organization and other international aid organizations. Conclusions This EVD epidemic had a considerable impact on the public health system and influenced the prevalence of HIV found among suspected cases in Sierra Leone, but also provided an opportunity to establish a better surveillance network for infectious diseases.http://link.springer.com/article/10.1186/s40249-019-0525-9HIVHCVEbolaPrevalenceSierra Leone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
William J. Liu Hai-Yang Hu Qiu-Dong Su Zhe Zhang Yang Liu Yu-Lan Sun Xian-Da Yang Da-Peng Sun Shao-Jian Cai Xiu-Xu Yang Idrissa Kamara Abdul Kamara Matt Lebby Brima Kargbo Patricia Ongpin Xiao-Ping Dong Yue-Long Shu Wen-Bo Xu Gui-Zhen Wu Michael Gboun George F. Gao |
spellingShingle |
William J. Liu Hai-Yang Hu Qiu-Dong Su Zhe Zhang Yang Liu Yu-Lan Sun Xian-Da Yang Da-Peng Sun Shao-Jian Cai Xiu-Xu Yang Idrissa Kamara Abdul Kamara Matt Lebby Brima Kargbo Patricia Ongpin Xiao-Ping Dong Yue-Long Shu Wen-Bo Xu Gui-Zhen Wu Michael Gboun George F. Gao HIV prevalence in suspected Ebola cases during the 2014–2016 Ebola epidemic in Sierra Leone Infectious Diseases of Poverty HIV HCV Ebola Prevalence Sierra Leone |
author_facet |
William J. Liu Hai-Yang Hu Qiu-Dong Su Zhe Zhang Yang Liu Yu-Lan Sun Xian-Da Yang Da-Peng Sun Shao-Jian Cai Xiu-Xu Yang Idrissa Kamara Abdul Kamara Matt Lebby Brima Kargbo Patricia Ongpin Xiao-Ping Dong Yue-Long Shu Wen-Bo Xu Gui-Zhen Wu Michael Gboun George F. Gao |
author_sort |
William J. Liu |
title |
HIV prevalence in suspected Ebola cases during the 2014–2016 Ebola epidemic in Sierra Leone |
title_short |
HIV prevalence in suspected Ebola cases during the 2014–2016 Ebola epidemic in Sierra Leone |
title_full |
HIV prevalence in suspected Ebola cases during the 2014–2016 Ebola epidemic in Sierra Leone |
title_fullStr |
HIV prevalence in suspected Ebola cases during the 2014–2016 Ebola epidemic in Sierra Leone |
title_full_unstemmed |
HIV prevalence in suspected Ebola cases during the 2014–2016 Ebola epidemic in Sierra Leone |
title_sort |
hiv prevalence in suspected ebola cases during the 2014–2016 ebola epidemic in sierra leone |
publisher |
BMC |
series |
Infectious Diseases of Poverty |
issn |
2049-9957 |
publishDate |
2019-03-01 |
description |
Abstract Background The 2014–2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease (EVD) in history. Clarifying the influence of other prevalent diseases such as human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) will help improve treatment and supportive care of patients with EVD. Case presentation We examined HIV and hepatitis C virus (HCV) antibody prevalence among suspected EVD cases from the Sierra Leone-China Friendship Biological Safety Laboratory during the epidemic in Sierra Leone. HIV and HCV antibodies were tested in 678 EVD-negative samples by enzyme-linked immunosorbent assay. A high HIV prevalence (17.6%) and low HCV prevalence (0.22%) were observed among the suspected cases. Notably, we found decreased HIV positive rates among the suspected cases over the course of the epidemic. This suggests a potentially beneficial effect of an improved public health system after assistance from the World Health Organization and other international aid organizations. Conclusions This EVD epidemic had a considerable impact on the public health system and influenced the prevalence of HIV found among suspected cases in Sierra Leone, but also provided an opportunity to establish a better surveillance network for infectious diseases. |
topic |
HIV HCV Ebola Prevalence Sierra Leone |
url |
http://link.springer.com/article/10.1186/s40249-019-0525-9 |
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