Advances in the Study of Heart Development and Disease Using Zebrafish
Animal models of cardiovascular disease are key players in the translational medicine pipeline used to define the conserved genetic and molecular basis of disease. Congenital heart diseases (CHDs) are the most common type of human birth defect and feature structural abnormalities that arise during c...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-04-01
|
Series: | Journal of Cardiovascular Development and Disease |
Subjects: | |
Online Access: | http://www.mdpi.com/2308-3425/3/2/13 |
id |
doaj-ddb5bbba2dd2448db8258296e8acfd0e |
---|---|
record_format |
Article |
spelling |
doaj-ddb5bbba2dd2448db8258296e8acfd0e2020-11-24T22:53:47ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252016-04-01321310.3390/jcdd3020013jcdd3020013Advances in the Study of Heart Development and Disease Using ZebrafishDaniel R. Brown0Leigh Ann Samsa1Li Qian2Jiandong Liu3Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Cell Biology and Physiology; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAAnimal models of cardiovascular disease are key players in the translational medicine pipeline used to define the conserved genetic and molecular basis of disease. Congenital heart diseases (CHDs) are the most common type of human birth defect and feature structural abnormalities that arise during cardiac development and maturation. The zebrafish, Danio rerio, is a valuable vertebrate model organism, offering advantages over traditional mammalian models. These advantages include the rapid, stereotyped and external development of transparent embryos produced in large numbers from inexpensively housed adults, vast capacity for genetic manipulation, and amenability to high-throughput screening. With the help of modern genetics and a sequenced genome, zebrafish have led to insights in cardiovascular diseases ranging from CHDs to arrhythmia and cardiomyopathy. Here, we discuss the utility of zebrafish as a model system and summarize zebrafish cardiac morphogenesis with emphasis on parallels to human heart diseases. Additionally, we discuss the specific tools and experimental platforms utilized in the zebrafish model including forward screens, functional characterization of candidate genes, and high throughput applications.http://www.mdpi.com/2308-3425/3/2/13zebrafishcongenital heart diseasecardiomyopathycardiac arrhythmiadevelopmenttranslational medicinedrug screens |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel R. Brown Leigh Ann Samsa Li Qian Jiandong Liu |
spellingShingle |
Daniel R. Brown Leigh Ann Samsa Li Qian Jiandong Liu Advances in the Study of Heart Development and Disease Using Zebrafish Journal of Cardiovascular Development and Disease zebrafish congenital heart disease cardiomyopathy cardiac arrhythmia development translational medicine drug screens |
author_facet |
Daniel R. Brown Leigh Ann Samsa Li Qian Jiandong Liu |
author_sort |
Daniel R. Brown |
title |
Advances in the Study of Heart Development and Disease Using Zebrafish |
title_short |
Advances in the Study of Heart Development and Disease Using Zebrafish |
title_full |
Advances in the Study of Heart Development and Disease Using Zebrafish |
title_fullStr |
Advances in the Study of Heart Development and Disease Using Zebrafish |
title_full_unstemmed |
Advances in the Study of Heart Development and Disease Using Zebrafish |
title_sort |
advances in the study of heart development and disease using zebrafish |
publisher |
MDPI AG |
series |
Journal of Cardiovascular Development and Disease |
issn |
2308-3425 |
publishDate |
2016-04-01 |
description |
Animal models of cardiovascular disease are key players in the translational medicine pipeline used to define the conserved genetic and molecular basis of disease. Congenital heart diseases (CHDs) are the most common type of human birth defect and feature structural abnormalities that arise during cardiac development and maturation. The zebrafish, Danio rerio, is a valuable vertebrate model organism, offering advantages over traditional mammalian models. These advantages include the rapid, stereotyped and external development of transparent embryos produced in large numbers from inexpensively housed adults, vast capacity for genetic manipulation, and amenability to high-throughput screening. With the help of modern genetics and a sequenced genome, zebrafish have led to insights in cardiovascular diseases ranging from CHDs to arrhythmia and cardiomyopathy. Here, we discuss the utility of zebrafish as a model system and summarize zebrafish cardiac morphogenesis with emphasis on parallels to human heart diseases. Additionally, we discuss the specific tools and experimental platforms utilized in the zebrafish model including forward screens, functional characterization of candidate genes, and high throughput applications. |
topic |
zebrafish congenital heart disease cardiomyopathy cardiac arrhythmia development translational medicine drug screens |
url |
http://www.mdpi.com/2308-3425/3/2/13 |
work_keys_str_mv |
AT danielrbrown advancesinthestudyofheartdevelopmentanddiseaseusingzebrafish AT leighannsamsa advancesinthestudyofheartdevelopmentanddiseaseusingzebrafish AT liqian advancesinthestudyofheartdevelopmentanddiseaseusingzebrafish AT jiandongliu advancesinthestudyofheartdevelopmentanddiseaseusingzebrafish |
_version_ |
1725661803798593536 |