Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.)
Abstract Leishmaniasis is an endemic disease caused by protozoa of the genus Leishmania, which affects around two million people worldwide. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Medicinal and aromatic plants constitute a maj...
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doaj-ddbb1bd840ab4087a00728df56ce55e72020-11-24T21:14:29ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26909032671267810.1590/0001-3765201820170332S0001-37652018000602671Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.)PRISCILA M. DE ANDRADEDAIANA C. DE MELOANA ELISA T. ALCOBAWALNIR G. FERREIRA JÚNIORMARIANA C. PAGOTTILIZANDRA G. MAGALHÃESTAINÁ C.L. DOS SANTOSANTÔNIO E.M. CROTTICASSIA C.F. ALVESMAYKER L.D. MIRANDAAbstract Leishmaniasis is an endemic disease caused by protozoa of the genus Leishmania, which affects around two million people worldwide. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Medicinal and aromatic plants constitute a major source of natural organic compounds. In this study, the leaf essential oil of Cryptocarya aschersoniana was obtained by hydrodistillation in a Clevenger-type apparatus, and the chemical composition was analyzed by GC-MS and GC-FID. The essential oil of these species was predominantly constituted by monoterpene hydrocarbons (48.8%). Limonene (42.3%), linalool (9.7%) and nerolidol (8.6%) were the main constituents in the oil of C. aschersoniana. The in vitro activity of the oil was evaluated against the promastigote forms of Leishmania amazonensis, the causative agent of cutaneous leishmaniasis in humans. The essential oil of C. aschersoniana showed high activity against L. amazonensis promastigote forms (IC50 = 4.46 µg/mL), however, it also demonstrated a relatively high cytotoxicity on mouse peritoneal macrophages (CC50 = 7.71 µg/mL). This is the first report of the chemical composition and the leishmanicidal and cytotoxic activities of the leaf essential oil of C. aschersoniana.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602671&lng=en&tlng=enCryptocarya aschersonianaLauraceaeessential oilLeishmania amazonensiscytotoxic activity |
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DOAJ |
language |
English |
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DOAJ |
author |
PRISCILA M. DE ANDRADE DAIANA C. DE MELO ANA ELISA T. ALCOBA WALNIR G. FERREIRA JÚNIOR MARIANA C. PAGOTTI LIZANDRA G. MAGALHÃES TAINÁ C.L. DOS SANTOS ANTÔNIO E.M. CROTTI CASSIA C.F. ALVES MAYKER L.D. MIRANDA |
spellingShingle |
PRISCILA M. DE ANDRADE DAIANA C. DE MELO ANA ELISA T. ALCOBA WALNIR G. FERREIRA JÚNIOR MARIANA C. PAGOTTI LIZANDRA G. MAGALHÃES TAINÁ C.L. DOS SANTOS ANTÔNIO E.M. CROTTI CASSIA C.F. ALVES MAYKER L.D. MIRANDA Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.) Anais da Academia Brasileira de Ciências Cryptocarya aschersoniana Lauraceae essential oil Leishmania amazonensis cytotoxic activity |
author_facet |
PRISCILA M. DE ANDRADE DAIANA C. DE MELO ANA ELISA T. ALCOBA WALNIR G. FERREIRA JÚNIOR MARIANA C. PAGOTTI LIZANDRA G. MAGALHÃES TAINÁ C.L. DOS SANTOS ANTÔNIO E.M. CROTTI CASSIA C.F. ALVES MAYKER L.D. MIRANDA |
author_sort |
PRISCILA M. DE ANDRADE |
title |
Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.) |
title_short |
Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.) |
title_full |
Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.) |
title_fullStr |
Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.) |
title_full_unstemmed |
Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.) |
title_sort |
chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of cryptocarya aschersoniana mez. (lauraceae juss.) |
publisher |
Academia Brasileira de Ciências |
series |
Anais da Academia Brasileira de Ciências |
issn |
1678-2690 |
description |
Abstract Leishmaniasis is an endemic disease caused by protozoa of the genus Leishmania, which affects around two million people worldwide. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Medicinal and aromatic plants constitute a major source of natural organic compounds. In this study, the leaf essential oil of Cryptocarya aschersoniana was obtained by hydrodistillation in a Clevenger-type apparatus, and the chemical composition was analyzed by GC-MS and GC-FID. The essential oil of these species was predominantly constituted by monoterpene hydrocarbons (48.8%). Limonene (42.3%), linalool (9.7%) and nerolidol (8.6%) were the main constituents in the oil of C. aschersoniana. The in vitro activity of the oil was evaluated against the promastigote forms of Leishmania amazonensis, the causative agent of cutaneous leishmaniasis in humans. The essential oil of C. aschersoniana showed high activity against L. amazonensis promastigote forms (IC50 = 4.46 µg/mL), however, it also demonstrated a relatively high cytotoxicity on mouse peritoneal macrophages (CC50 = 7.71 µg/mL). This is the first report of the chemical composition and the leishmanicidal and cytotoxic activities of the leaf essential oil of C. aschersoniana. |
topic |
Cryptocarya aschersoniana Lauraceae essential oil Leishmania amazonensis cytotoxic activity |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602671&lng=en&tlng=en |
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