Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment
Abstract Background The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA). Methods Post-hoc analysis of 439 RA patients (67.3% rheumatoid factor positive) with...
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doaj-ddbedcb42a224131ae7c3a0b9702e2e32020-11-25T03:48:48ZengBMCBMC Rheumatology2520-10262019-06-01311810.1186/s41927-019-0071-xPredictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatmentMarjan Ghiti Moghadam0Femke B. G. Lamers-Karnebeek1Harald E. Vonkeman2Peter M. ten Klooster3Janneke Tekstra4Barbara van Schaeybroeck5Ruth Klaasen6Marieke van Onna7Hein J. Bernelot Moens8Henk Visser9Annemarie M. Schilder10Marc R. Kok11Robert B. M. Landewé12Piet L. C. M. van Riel13Mart A. F. J. van de Laar14Tim L. Jansen15on behalf of the Dutch National POET CollaborationDepartment of Rheumatology, Medisch Spectrum TwenteDepartment of Rheumatology, Radboud University Medical CenterDepartment of Rheumatology, Medisch Spectrum TwenteDepartment of Psychology, Health & Technology, University of TwenteDepartment of Rheumatology, University Medical Center UtrechtDepartment of Rheumatology, Albert Schweitzer HospitalDepartment of Rheumatology, Meander Medical CentreDepartment of Clinical Immunology and Rheumatology, Academic Medical CenterDepartment of Rheumatology, Ziekenhuis Groep TwenteDepartment of Rheumatology, RijnstateDepartment of Rheumatology, Medical Centre LeeuwardenDepartment of Rheumatology and Clinical Immunology, Maasstad HospitalDepartment of Clinical Immunology and Rheumatology, Academic Medical CenterDepartment of IQ Healthcare, Radboud University Medical CenterDepartment of Rheumatology, Medisch Spectrum TwenteDepartment of Rheumatology, VieCuri Medical CenterAbstract Background The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA). Methods Post-hoc analysis of 439 RA patients (67.3% rheumatoid factor positive) with longstanding RA in remission or with stable low disease activity, randomized to stopping TNFi treatment in the multicenter POET trial. Prolonged acceptable disease control was defined as not restarting TNFi treatment within 12 months after stopping. Baseline demographic and disease-related variables were included in univariate and multivariate logistic regression analysis for identifying predictors of relapse. Results One year after baseline, 220 patients (50.1%) had not restarted TNFi treatment. Use of an anti-TNF monoclonal antibody (versus a receptor antagonist, OR = 2.41; 95% CI: 1.58–3.67), ≤10 yrs. disease duration (OR = 2.15; 95% CI: 1.42–3.26) and low or moderate multi-biomarker disease activity (MBDA) scores (OR = 2.00; 95% CI: 1.10–3.64) at baseline were independently predictive of successful TNFi discontinuation (area under the receiver operating characteristic curve = 0.66; 95% CI: 0.61–0.71). Results were similar when using no physician-reported flare as the criterion. TNFi-free survival was significantly different for patient groups based on the number of predictors present, ranging from 21.4% of patients with no predictor present to 66.7% of patients with all three predictors present. Conclusion Patients using an anti-TNF monoclonal antibody, with shorter disease duration and low or moderate baseline MBDA score are most likely to achieve prolonged disease control after TNFi discontinuation. Trial registration Netherlands Trial Register NTR3112, 21 October 2011.http://link.springer.com/article/10.1186/s41927-019-0071-xRheumatoid arthritisRemissionLow disease activityTNFi discontinuationPredictors |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marjan Ghiti Moghadam Femke B. G. Lamers-Karnebeek Harald E. Vonkeman Peter M. ten Klooster Janneke Tekstra Barbara van Schaeybroeck Ruth Klaasen Marieke van Onna Hein J. Bernelot Moens Henk Visser Annemarie M. Schilder Marc R. Kok Robert B. M. Landewé Piet L. C. M. van Riel Mart A. F. J. van de Laar Tim L. Jansen on behalf of the Dutch National POET Collaboration |
spellingShingle |
Marjan Ghiti Moghadam Femke B. G. Lamers-Karnebeek Harald E. Vonkeman Peter M. ten Klooster Janneke Tekstra Barbara van Schaeybroeck Ruth Klaasen Marieke van Onna Hein J. Bernelot Moens Henk Visser Annemarie M. Schilder Marc R. Kok Robert B. M. Landewé Piet L. C. M. van Riel Mart A. F. J. van de Laar Tim L. Jansen on behalf of the Dutch National POET Collaboration Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment BMC Rheumatology Rheumatoid arthritis Remission Low disease activity TNFi discontinuation Predictors |
author_facet |
Marjan Ghiti Moghadam Femke B. G. Lamers-Karnebeek Harald E. Vonkeman Peter M. ten Klooster Janneke Tekstra Barbara van Schaeybroeck Ruth Klaasen Marieke van Onna Hein J. Bernelot Moens Henk Visser Annemarie M. Schilder Marc R. Kok Robert B. M. Landewé Piet L. C. M. van Riel Mart A. F. J. van de Laar Tim L. Jansen on behalf of the Dutch National POET Collaboration |
author_sort |
Marjan Ghiti Moghadam |
title |
Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment |
title_short |
Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment |
title_full |
Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment |
title_fullStr |
Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment |
title_full_unstemmed |
Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment |
title_sort |
predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment |
publisher |
BMC |
series |
BMC Rheumatology |
issn |
2520-1026 |
publishDate |
2019-06-01 |
description |
Abstract Background The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA). Methods Post-hoc analysis of 439 RA patients (67.3% rheumatoid factor positive) with longstanding RA in remission or with stable low disease activity, randomized to stopping TNFi treatment in the multicenter POET trial. Prolonged acceptable disease control was defined as not restarting TNFi treatment within 12 months after stopping. Baseline demographic and disease-related variables were included in univariate and multivariate logistic regression analysis for identifying predictors of relapse. Results One year after baseline, 220 patients (50.1%) had not restarted TNFi treatment. Use of an anti-TNF monoclonal antibody (versus a receptor antagonist, OR = 2.41; 95% CI: 1.58–3.67), ≤10 yrs. disease duration (OR = 2.15; 95% CI: 1.42–3.26) and low or moderate multi-biomarker disease activity (MBDA) scores (OR = 2.00; 95% CI: 1.10–3.64) at baseline were independently predictive of successful TNFi discontinuation (area under the receiver operating characteristic curve = 0.66; 95% CI: 0.61–0.71). Results were similar when using no physician-reported flare as the criterion. TNFi-free survival was significantly different for patient groups based on the number of predictors present, ranging from 21.4% of patients with no predictor present to 66.7% of patients with all three predictors present. Conclusion Patients using an anti-TNF monoclonal antibody, with shorter disease duration and low or moderate baseline MBDA score are most likely to achieve prolonged disease control after TNFi discontinuation. Trial registration Netherlands Trial Register NTR3112, 21 October 2011. |
topic |
Rheumatoid arthritis Remission Low disease activity TNFi discontinuation Predictors |
url |
http://link.springer.com/article/10.1186/s41927-019-0071-x |
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