Molecular Profiling of Aggressive Lymphomas

In the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinica...

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Main Authors:	Maura Rossi, Maria Antonella Laginestra, Anna Gazzola, Maria Rosaria Sapienza, Stefano A. Pileri, Pier Paolo Piccaluga
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Advances in Hematology
Online Access:	http://dx.doi.org/10.1155/2012/464680

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spelling	doaj-ddbeef592c18464483a06d7c9f8521032021-07-02T02:06:29ZengHindawi LimitedAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/464680464680Molecular Profiling of Aggressive LymphomasMaura Rossi0Maria Antonella Laginestra1Anna Gazzola2Maria Rosaria Sapienza3Stefano A. Pileri4Pier Paolo Piccaluga5Molecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyMolecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyMolecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyMolecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyMolecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyMolecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology “L. and A. Seràgnoli”, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyIn the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinical features. In addition, it was demonstrated that DLBCLs are distinct from BL. Indeed, the latter is a unique molecular entity. However, relevant pathological differences emerged among the clinical subtypes. More recently, microRNA profiling provided further information concerning BL-DLBCL distinction as well as for their subclassification. In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas.http://dx.doi.org/10.1155/2012/464680
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maura Rossi Maria Antonella Laginestra Anna Gazzola Maria Rosaria Sapienza Stefano A. Pileri Pier Paolo Piccaluga
spellingShingle	Maura Rossi Maria Antonella Laginestra Anna Gazzola Maria Rosaria Sapienza Stefano A. Pileri Pier Paolo Piccaluga Molecular Profiling of Aggressive Lymphomas Advances in Hematology
author_facet	Maura Rossi Maria Antonella Laginestra Anna Gazzola Maria Rosaria Sapienza Stefano A. Pileri Pier Paolo Piccaluga
author_sort	Maura Rossi
title	Molecular Profiling of Aggressive Lymphomas
title_short	Molecular Profiling of Aggressive Lymphomas
title_full	Molecular Profiling of Aggressive Lymphomas
title_fullStr	Molecular Profiling of Aggressive Lymphomas
title_full_unstemmed	Molecular Profiling of Aggressive Lymphomas
title_sort	molecular profiling of aggressive lymphomas
publisher	Hindawi Limited
series	Advances in Hematology
issn	1687-9104 1687-9112
publishDate	2012-01-01
description	In the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinical features. In addition, it was demonstrated that DLBCLs are distinct from BL. Indeed, the latter is a unique molecular entity. However, relevant pathological differences emerged among the clinical subtypes. More recently, microRNA profiling provided further information concerning BL-DLBCL distinction as well as for their subclassification. In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas.
url	http://dx.doi.org/10.1155/2012/464680
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Molecular Profiling of Aggressive Lymphomas

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